Signaling pathways regulate contraction of striated (skeletal and cardiac) and smooth muscle. Although these are similar, there are striking differences in the pathways that can be attributed to the distinct functional roles of the different muscle types. Muscles contract in response to depolarization,...
Signaling in muscle atrophy and hypertrophy.AnimalsHumansMuscle, SkeletalMuscular AtrophyHypertrophyContractile ProteinsSignal TransductionMuscle ContractionMuscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, ...
Inflammation Inhibits Muscarinic Signaling in In Vivo Canine Colonic Circular Smooth Muscle Cells SUDARSHAN RAO JADCHERLA Sections of Neonatology, Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A. ABSTRACT We investigated the ...
by usingALPK3reporter and mutant human pluripotent stem cell (hPSC) lines, as well as mass spectrometry, to define the role of ALPK3 in muscle contraction and signaling. Our data demonstrate that ALPK3 localizes to the M-band of the sarcomere, which is a key regulatory node of sarcomere ...
Neurotransmitter, any of a group of chemical substances released by neurons to stimulate other neurons or muscle or gland cells. Signaling by neurotransmitters allows impulses to be passed from one cell to the next throughout the nervous system. Learn mo
It has been known that the contraction of Skeletal muscle can induce the generation of ROS,which can lead to the rising of oxidative stress levels,and the antioxidant defence system activated as a response at the same time.NFκB and MAPK pathways are the two main ROS-sensitivity signalling pat...
Because p38 MAPK/HSP25 signaling has been implicated in smooth muscle contraction, we examined its role in cadmium-induced contraction of mesangial cells. We report that exposure of mesangial cells to cadmium resulted in 1) cell contraction, 2) activation of MAP kinases, 3) increased HSP25 ...
The role of reactive oxygen species and nitric oxide in the regulation of skeletal muscle glucose uptake during contraction There is evidence that reactive oxygen species (ROS) and nitric oxide (NO) are involved in the regulation of skeletal muscle glucose uptake during contract... TL Merry - Me...
Musclespecific transgenic complementation of GLUT4-deficient mice. Effects on glucose but not lipid metabolism. J. Clin. Invest. 100: 671–677, 1997. CrossRef Wallberg-Henriksson, H., and J. O. Holloszy. Activation of glucose transport by muscle contraction in severely diabetic rats. Am. ...
in muscle, the dystrophin glycoprotein complex (DGC), and the desmosomal component plakoglobin (γ-catenin). The integrity of this high-molecular-mass assembly renders skeletal muscle susceptibility to insulin, because DGC-insulin receptor dissociation by plakoglobin downregulation reduces insulin signaling...