Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA. J Psychopharmacol 2009;23(8):923-35. http://dx.doi.org/10.1177/0269881108094650.Hasler F, Studerus E, Lindner K, Ludewig S, Vollenweider FX. Investiga- tion of serotonin-1A receptor function in the human...
The serotonin-1A (5-HT1A) receptor is strongly implicated in major depression and other affective disorders due to its negative regulation of serotonin neurone firing rates. Behavioural and clinical studies have repeatedly reported that the −1019G all
Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA. J Psychopharmacol 2009;23(8):923-35. http://dx.doi.org/10.1177/... FHESK Lindner - 《Journal of Psychopharmacology》 被引量: 0发表: 2009年 NMDA Receptor Function and Human Cognition: The Effects of Ketam...
At present, 14 different serotonin receptors have been described and, although the function and localization of many of these receptors is becoming increasingly clear, much remains unknown. The SSRIs are intriguing drugs; by blocking presynaptic and somatodendritic serotonin transporters, they enhance ...
These data show that altered 5-HT1A autoreceptor regulation in male Deaf1-/-mice can be compensated for by generational adaptation of receptor response that may help to normalize behavior. The sex dependence of Deaf1 function in mice is consistent with a greater role for 5-HT1A autoreceptors ...
To determine whether the increase in autoreceptor levels in Deaf-1-deficient animals altered serotonergic function, immunofluorescence was done using anti-5-HT antibody to detect serotonin in the DRN (Fig. 7A). As observed for TPH+ cells, there was no change in the number of 5-HT-positive ...
To elucidate how these actions could potentially regulate prefrontal circuit function, we infused a 5-HT1B agonist into the mPFC of freely behaving mice. Consistent with previous studies that have optogenetically inhibited vHPC-mPFC projections, activating prefrontal 5-HT1B receptors suppressed theta-...
Serotonin-1a receptor regulation of seizure-induced hippocampal neurogenesis and its role in the development of experimental temporal lobe epilepsy in the rat.Radley, Jason James
To the best of our knowledge, these results constitute the first report describing the effect of chronic cholesterol depletion on the organization and function of a G-protein-coupled neuronal receptor. Our results assume significance in view of recent reports highlighting the symptoms of anxiety and ...
The 5-HT_(1A) receptor binding potential (BP_(ND)) was quantified for the dorsal raphe nucleus (DRN) using a region-of-interest approach and for the entire brain by calculating parametric maps. Voxel-wise linear regression was applied between DRN autoreceptor and whole-brain heteroreceptor 5...