ROR gamma t(+) regulatory T (Treg) cells are critical toward maintaining gut immune tolerance. In recent studies published in Nature, Kedmi et al., Lyu et al., and Akagbosu et al. describe MHCII+ROR gamma t(+) antigen-presenting cells that mediate ROR gamma t(+) Treg cell ...
目的:⑴了解肝癌患者外周血中是否存在Treg优势化现象.⑵研究肝癌患者外周血中Th1,Th2,Th17及Treg各自的主要转录因子T-bet,GATA-3,RORgammat 及FOXP3的表达情况. 方法:抽取实验组20例肝癌患者与对照组20例健康志愿者的外周静脉血,采用流式细胞术检测外周静脉血单个核细胞中CD4+CD25+T细胞占CD4+细胞比例;采用荧光定...
目的:一、了解肝癌患者外周血中是否存在Treg优势化现象。二、研究肝癌患者外周血中Th1、Th2、Th17及Treg各自的主要转录因子T-bet、GATA-3、RORgammat及FOXP3的表达情况。材料与方法:抽取实验组20例肝癌患者与对照组20例健康志愿者的外周静脉血,采用流式细胞术检测外周静脉血单个核细胞中CD4+CD25+T细胞占CD4+细胞...
The inhibitory function of Treg cells of Tg mice was equal to that of wild-type mice in vitro. The abundant Treg cells of Tg mice could suppress the development of sialadenitis, but the reduced Treg cells of Tg mice could not inhibit the induction of sialadenitis in Rag2(-/-) mice ...
This study investigated the expression of several subtypes of TILs including T helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) cells to determine their correlation with clinicopathologic features and postoperative prognosis. 展开 年份: 2016 ...
Rejection of transplanted liver occurs when the host generates alloantigen-reactive T cells, and CD4 + T-cell subsets, including Th1, Th2, T17 and iTreg, c... X Min - 《Transplant Immunology》 被引量: 12发表: 2010年 gata3 drives development of ror t + group 3 innate lymphoid cells ...
T(h) cells have long been divided into two subsets, T(h)1 and T(h)2; however, recently, T(h)17 and inducible regulatory T (iTreg) cells were identified as ... K Ichiyama,M Hashimoto,T Sekiya,... - 《International Immunology》 被引量: 64发表: 2009年 299 A NEW SYNDROME OF SHO...
T cell-specific Ddx5 knockout (DDX5 Delta T) mice have augmented ROR gamma t+ Treg suppressor activities and are better protected from intestinal inflammation. Genetic ablation or pharmacologic inhibition of HIF1 alpha restores enteropathy susceptibility in DDX5 Delta T mice. The DDX5-HI-F1 ...
(IL)-17 family of cytokines during Th17 cell differentiation.FoxP3 can directly interact with and negatively regulate the function of RORγt,to determine the balance between induced Treg(iTreg)and Th17 cell polarization.Two recent independent studies from the Pan and Chi Labs have shown how ...
TregRegulatory T cells (Tregs) exert inhibitory function under various physiological conditions and adopt diverse characteristics following environmental cues. Multiple subsets of Tregs expressing master transcription factors of helper T cells such as ROR gamma t, T-bet, Gata3 and PPAR gamma have been...