Objective To investigate the role of nuclear factor kappa-B(NF-κB)signaling pathway in tumor necrosis factor α(TNF-α)-induced apoptosis in gastric cancer cells.Methods Human gastric cancer cell line SGC7901 was treated with TNF-α for 24 hours.MTT assay,flowcytometry and Western blot was us...
These pathways play a central role in the differentiation, proliferation, and evasion of apoptosis. Studies have shown the importance of these pathways in the breast cancer tumor microenvironment (TME). The breast cancer TME has high inflammation strengthened by the infiltrated immune cells, growth ...
TLR4/MyD88/NF-kappa B signaling pathwayCoronary microembolization (CME) is a common complication during the treatment of acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). Nicorandil can be used to prevent myocardial injury after PCI to reduce the incidence of coronary no-...
CAFs (cancer-associated fibroblasts) are highly flexible cells of the cancer microenvironment. They produce the extracellular matrix (ECM) constituents that form the structure of the tumor stroma but are also a source of metabolites, growth factors, chemokines, and exosomes that impact every aspect o...
In recent years, emerging evidence suggest involvement of K63-linked ubiquitination in multiple signaling pathways and various human diseases including cancer. Increasing number of studies indicated that K63-linked ubiquitination controls initiation, development, invasion, metastasis, and therapy of diverse ...
H23 and Panc-1 cancer cells were pretreated with UK-101, LKS01 or epoxomicin (a prototypic inhibitor targeting both the constitutive proteasome and immunoproteasome). We then examined whether these pretreatments lead to any defect in activating the canonical NF-κB pathway following TNFα exposure ...
in cancer cells [26]. Among the various stimuli, the TNFα/TNFR signaling pathway is considered a prototype and has been the most intensively investigated [14]. Thus, the initiation of necroptosis can be epitomized by the events occurring in the TNF signaling pathway. The binding of TNF to ...
CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death receptor/death ligand system that mediates apoptosis induction to maintain immune homeostasis. In addition, these molecules are important in the immune elimination of virus-infected
Breast cancer has grown to be the second leading cause of cancer-related deaths in women. Only a few treatment options are available for breast cancer due to the widespread occurrence of chemoresistance, which emphasizes the need to discover and develop
In the hemostasis phase, the wound starts to be closed by clotting. Hemostasis begins just after blood leaks out of the body. At fifirst, blood vessels constrict in order to restrict the blood flflow. Then, the platelets coagulate to form a plug, while subsequently, a number of fifibri...