Hibino T, Nishiyama T. Role of TGF-b2 in the human hair cycle. J Dermatol Sci 2004; 35:9-18.Hibino T & Nishiyama T 2004 Role of TGF-b2 in the human hair cycle. Journal of Dermatology Science 35 9-18.Hibino T, Nishiyama T 2004 Role of TGF-2 in the human hair cycle. J ...
Furthermore, the healing employs a blastema-like structure similar to that seen in amphibian regenerating tissue. Cells from the MRL mouse display DNA damage, cell cycle G2/M arrest, and a reduced level of p21CIP1/WAF. A functional role for p21 was confirmed when tissue injury in an ...
The intestinal epithelium is one of the most rapidly self-renewing tissues in adult mammals and is characterized by cell turnover every 3–5 days [1]. This turnover is significantly influenced by microbial colonization, which induces rapid epithelial turnover in the intestines [2,3]. Given the...
Furthermore, FGF signaling can also stimulate the signal transducers and activators of tran- scription (STAT) 1/p21 pathway2,7 (Figure 1). Multiple kinds of mouse models with genetic modifications of FGF/FGFR have been generated. In our review, we summarize the use of these mouse models in...
BetaPowered by GenAIThis is generative AI content and the quality may vary. Learn more. How do the functions of Long Noncoding Rnas (lncRNAs) differ in the context of skin cancer progression? What potential roles do Non Coding RNAs (nc-RNAs) have as biomarkers or therapeutic targets in ...
Many genetic advances have also been made in identifying Single Nucleotide Polymorphisms (SNPs) and mutations in the human NLRP1 gene on chromosome 17 that make significant impacts on human disease. The location of these SNPs can help lead to a greater understanding of NLRP1 function. For ...
ENO1, also called 2-phospho-D-glycerate hydrolase in cellular glycolysis, is an enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate and plays an important role in the Warburg effect. In various tumors, ENO1 overexpression correlates with poor
intensive cell proliferation, invasiveness, cell migration, the convergence of signaling pathways, important roles of proto-oncogenes and tumor suppressor genes, similarities in gene expression and differentiation, cell adhesion and apoptosis, epithelial-mesenchymal transition, and cell plasticity [1, 2]....
Annexin2, serotonin 1B receptor Downregulated in depressive-like states. Implicated in the action of antidepressant drugs and electroconvulsive seizures due to its interaction with serotonin receptors. Induced by EGF, TGF-α, IFN-γ, NGF, KGF, RA and thrombin, and by the oncogenes PML-RARα an...
Introduction In normoxic conditions, glucose is fully metabolized into carbon dioxide and water by the tricarboxylic acid cycle and oxidative phosphorylation, creating large amounts of ATP. However, even under well-oxygenated conditions, tumor cells generate energy by aerobic glycolysis rather than ...