TRPV4 regulates lipid-laden macrophage foam cell formation, the hallmark of atheroinflammatory conditions, in response to matrix stiffness and lipopolysaccharide stimulation. Accumulating data also point to a role of macrophage TRPV4 in the pathogenesis of the foreign body response, a chronic ...
Role of macrophage TRPV4 in inflammation.doi:10.1038/s41374-019-0334-6Bidisha DuttaRakesh K. AryaRishov GoswamiMazen O. AlharbiShweta SharmaShaik O. RahamanLab Invest
As such, we have now entered a time where the therapeutic potential of TRPV4 inhibitors can be systematically examined in a variety of lung diseases. Due to this fact, this review seeks to describe the current state of the art with respect to the role of TRPV4 in pulmonary homeostasis and...
In recent years, the biological role of changes in physical factors in carcinogenesis and progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is a critical physical factor of tumor microenvironment and remains alte
Stroke is one of the major causes of mortality and morbidity worldwide, yet novel therapeutic treatments for this condition are lacking. This review focuses on the roles of the transient receptor potential melastatin 2 (TRPM2) ion channels in cellular da
Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and cytokine receptor signal transduction. They are involved in the regulation of bone metabolism of bone precursor cells, mesenchymal stem cells (MSCs), osteoblasts (OBs)
Intraplantar injection of AITC also caused nociception. NADPH oxidase or SOD activity and H2O2 levels were increased in the sciatic nerve and hind paw skin samples. The 4T1 cells did not express TRPA1, and the use of HC-030031 or α-lipoic acid did not reduce the cytotoxic effect of a ...
Fig. 8. PDMS substrate stimulation evoking [Ca2+]i oscillations at substrate stiffness of (A) 197 kPa, (B) 78 kPa, (C) 54 kPa, or (D) 2 kPa in control siRNA-treated chondrocytes (Control), TRPV4-KD cells (TRPV4-KD), Piezo1-KD cells (Piezo1-KD), and Piezo2-KD cells (Piezo...
A differential role of macrophage TRPM2 channels in Ca2+ signaling and cell death in early responses to H2O2. Am J Physiol Cell Physiol 2013; 305: C61–9. 53 Lange I, Penner R, Fleig A, Beck A. Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human ...
et al. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58, 718–725 (2009). Article CAS PubMed PubMed Central Google Scholar Goossens, G. H. et al. Increased adipose tissue oxygen ...