Here we use cryo-electron microscopy to determine a series of the small mitoribosomal subunit (SSU) intermediates in complex with auxiliary factors, revealing a sequential assembly mechanism. The methyltransferase TFB1M binds to partially unfolded rRNA h45 that is promoted by RBFA, while the mRNA ...
The folding of ribosomal RNAs is central to the biogenesis of the mitoribosome and is a complex, stepwise process. Five recent cryo-EM studies detail the late steps of the folding and maturation of the human mitoribosomal large subunit RNA that forms the catalytic core of the ribosome: the ...
Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit 来自 EBSCO 喜欢 0 阅读量: 43 作者:J Perez-Fernandez,CM Braun 摘要: More than 200 assembly factors (AFs) are required for the production of ribosomes...
Biochemistry Quality Control and Organization of Small Ribosomal Subunit Biogenesis UNIVERSITY OF ROCHESTER Gloria M. Culver ConnollyKeithThe ribosome decodes mRNA messages and catalyzes protein synthesis (a process termed translation), making it one of the most fundamental structures in any living cell....
The Small Ribosomal Subunit Biogenesis GTPase A (RsgA) is a bacterial assembly factor involved in the late stages of the 30S subunit maturation. It is a multidomain GTPase in which the central circularly permutated GTPase domain is flanked by an OB domain and a Zn‐binding domain. All three...
(1997) Variable region V1 of Saccharomyces cerevisiae 18S rRNA participates in biogenesis and function of the small ribosomal subunit. Chromosoma, 105, 523-531.van Nues RW, Venema J, Planta RJ, Raue HA. Variable region V1 of Saccharomyces cerevisiae 18S rRNA participates in biogenesis and ...