综述了Rho GTPase家族典型亚家族成员RhoA,Cdc42和Rac1在耳蜗毛细胞的表达以及这些小分子蛋白是如何参与耳蜗毛细胞纤毛束的形态发生和外毛细胞运动,并且这些小分子作为感音神经性耳聋治疗的药物靶点的研究现状。
Proliferation of RhoA / cells was impaired due to a complete cell cycle block during mitosis, an effect that is associated with defective cytokinesis and chromosome segregation and can be readily rescued by exogenous expression of RhoA. Furthermore, RhoA deletion did not affect the transcriptional ...
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, an...
facilitated by a so called “GTPase activating/-accelerating protein” (GAP), which catalyzes the hydrolysis [14]. Thus, the release of the activated effector is induced and a new round of the activation-cycle can start (Fig.3). Besides GEFs and GAPs, the SmGs of the Rho/Rac/Cdc42- (...
As is already accepted in the field, RhoGTPases cycle between an active, GEF-induced and inactive, GAP-promoted state (reviewed in26). Our RhoGTPase FRET sensors shows reversible activation, and can thus be used both as GEF- as well as GAP-activity readouts, as deduced from the ...
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, ...
Localization of RhoA GTPase to Endothelial Caveolae-Enriched Membrane Domains 来自 NCBI 喜欢 0 阅读量: 48 作者:D Gingras,F Gauthier,S Lamy,RR Desrosiers,R Béliveau 摘要: Caveolae are small microdomains of the plasma membrane that are thought to play important roles in signal transduction processes...
Derk Frank1,2* and Ashraf Yusuf Rangrez1,2,3* Open Access Abstract The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally stud- ied in cancer cells where it was found to stimulate cell cycle progression and migration. ...
41. Kovary K, Bravo R: The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol 1991, 11:4466-4472. 42. Liu SY, Yen CY, Yang SC, Chiang WF, Chang KW: Overexpression of Rac-1 small GTPase binding protein in oral squamous cell ...
3). This cycle of palmitoylation/depalmitoylation promotes HRAS and NRAS shuttling between the PM and the Golgi and is thought to maintain specific intracellular compartmentalization that facilitates RAS signaling (Rocks et al., 2005). Interestingly, this cycle is regulated by another PTM: peptidyl-...