综述了Rho GTPase家族典型亚家族成员RhoA,Cdc42和Rac1在耳蜗毛细胞的表达以及这些小分子蛋白是如何参与耳蜗毛细胞纤毛束的形态发生和外毛细胞运动,并且这些小分子作为感音神经性耳聋治疗的药物靶点的研究现状。
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, an...
已识别出多个可选拼接变体。 This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate...
(Effector protein)相互作用,从而刺激细胞发生相应的响应;GTP酶激活蛋白(GTPase-activating proteins, GAPs)催化小GTP酶结合的GTP水解为GDP,并释放自由磷酸盐(Free phosphate, Pi),此时小GTP酶结合GDP进入静息状态(Inactive state),鸟嘌呤核苷酸解离抑制蛋白(Guanine nucleotide dissociation inhibitors, GDIs)抑制小GTP酶...
不同宫颈组织中rhoa nm23h1的表达及临床意义-expression and clinical significance of rhoa nm23h1 in different cervical tissues.docx,不同宫颈组织中 RhoA、 nm23-H1 的表达及临床意义 摘要 目的:研究在正常宫颈、宫颈上皮内瘤变及宫颈鳞癌组织中 RhoA、 nm23-H1 的表
Derk Frank1,2* and Ashraf Yusuf Rangrez1,2,3* Open Access Abstract The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally stud- ied in cancer cells where it was found to stimulate cell cycle progression and migration. ...
Gene SummaryThis gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, at...
Gene Summary This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, ...
Cellular biology Regulation of RhoA GTPase signaling by guanine nucleotide exchange factors in response to extracellular matrix adhesion and DNA damage THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Keith Burridge DubashAdi DaraThe Rho family of GTPases are proteins which regulate a large number of ...
(Effector protein)相互作用,从而刺激细胞发生相应的响应;GTP酶激活蛋白(GTPase-activating proteins, GAPs)催化小GTP酶结合的GTP水解为GDP,并释放自由磷酸盐(Free phosphate, Pi),此时小GTP酶结合GDP进入静息状态(Inactive state),鸟嘌呤核苷酸解离抑制蛋白(Guanine nucleotide dissociation inhibitors, GDIs)抑制小GTP酶...