Rocks: Multifunctional kinases in cell behaviour 2003, Nature Reviews Molecular Cell Biology RHO GTPASES in neuronal morphogenesis 2000, Nature Reviews Neuroscience View all citing articles on Scopus * This work was supported by research grants from the Ministry of Education, Science, Sports, and Cul...
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2. Nat Cell Biol 2008; 10: 314–321. 21. Riento K, Ridley AJ. Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 2003; 4: 446–456. 22. Kureishi Y, Kobayashi S, Amano M, Kimura K,...
Inactivation of Rho GTPases is due to an intrinsic GTPase activity, which hydrolyses GTP to GDP. However, this activity is very weak and needs to be up-regulated by GTPase activating enzymes (GAPs). Of note, Rnd1-3 [9] and RhoH [10,11] are not regulated via GAPs, due to their in...
Rho-associated kinases, known as ROCKs, are members of the cAMP-dependent protein kinase/protein kinase G/protein kinase C (AGC) family of serine/threonine kinases that includes G-protein-coupled receptor kinase (GRK) and protein kinase A (PKA). ...
Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out ...
S. & Minden, A. Dbl and the Rho GTPases activate NFκB by IκB kinase (IKK)-dependent and IKK-independent pathways. J. Biol. Chem. 276, 25876–25882 (2001). CAS PubMed Google Scholar Frost, J. A. et al. Stimulation of NFκB activity by multiple signaling pathways requires PAK1...
S. & Minden, A. Dbl and the Rho GTPases activate NFκB by IκB kinase (IKK)-dependent and IKK-independent pathways. J. Biol. Chem. 276, 25876–25882 (2001). CAS PubMed Google Scholar Frost, J. A. et al. Stimulation of NFκB activity by multiple signaling pathways requires PAK1...
LPA and serum, as well as TGF-β, could activate myofibroblast differentiation (135–138), which is supposedly one of the most potent stimulators of TFs (124). After glaucoma filtration surgery, TFs are likely to be exposed to LPA via serum and/or plasma, because the blood-aqueous humor ...
RHOGEFs bind to the GDP-bound form RHO GTPase and induce the exchange of GDP for GTP to activate RHO. Subsequently, the conformation of RHO GTPases changes, which allows them to interact with their specific effectors and triggers biological effects such as cell migration, polarity and ...
Rho GTPases play a key role in the spatio-temporal coordination of cytoskeletal dynamics during cell migration. Here, we directly investigate crosstalk between the major Rho GTPases Rho, Rac and Cdc42 by combining rapid activity perturbation with activit