Being the sole mitochondrial outer membrane protein associated with mitochondrial axonal transport-related processes, Miro proteins can be one of the key players in various NDs such as Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and Huntington's disease ...
近年研究报道线粒体Rho GTP酶1(mitochondrial Rho-GTPase 1,Miro1)与驱动蛋白连接,调控线粒体沿微管的运动[8-9]。Miro1是一种定位于线粒体外膜的GTP酶,可通过与接头蛋白(Milton)、驱动蛋白重链(kinesin heavy chain,KHC)等蛋白结合,形成功能性复合体,调控线粒体的运动。Fransson等[10]的研究报道Miro1的突变...
dMiro;Gem1;hMiro;Miro-1;Miro-2;Mitochondrial Rho GTPase 1-like;RHOT1 (Ras homolog family member T1);RHOT2;Rhot1;Rhot2; Historical Background The Ras superfamily family of small GTPases consists of GTP binding-dependent molecular switches with diverse cellular functions. Two isoforms of an ...
RhoH/TTF;RhoBTB(RhoBTB1,2)和Miro(MiID— l,21. 收稿日期:2003.12.3l 基金项目:国家自然科学基金资助项目(30170475) 作者简介:蔡军(1972--),男,讲师,博士研究生;易静(1957--),女,教授,博士生导师,?通 讯作者. 第3期蔡军,等:RhoGTPases和细胞凋亡l6l 2RhoGTPases基本功能 RhoGTPase,s是细胞骨架肌...
In RhoBTB3, the GTPase domain appears extensively erased, to the point that it is virtually unrecognizable as a GTPase. Only a short stretch at the end of the domain can be reliably aligned to the GT Pase domain of other subfamily members. Consequently, RhoBTB3 does not bind GTP in ...
MIRO1_HUMAN Antibody mitochondrial Rho (MIRO) GTPase 1 Antibody Mitochondrial Rho 1 Antibody Mitochondrial Rho GTPase 1 Antibody Mitochondrial Rho1 Antibody Rac GTP binding protein like protein Antibody Rac-GTP-binding protein-like protein Antibody Ras homolog family member T1 Antibody Ras homolog gene...
Rho 系列 GTPase 可服务于许多细胞功能,包括细胞信号转导、转录调节以及肌动蛋白细胞骨架的组织。该 GTPase 家族包括 Rho(RhoA、RhoB 和 RhoC)、Rac(Rac1、Rac2、Rac3 和 RhoG)、Cdc42(Cdc42 和 G25K)、Rnd(Rnd1、Rnd2 和 RhoE/Rnd3)、RhoBTB 家族和 Miro 家族。这些 GTPase 通过 GPCR、酪氨酸激酶、细...
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In this study, we systematically identified and characterized a total set (Rho,Rac,Mig,Cdc42,Tc10,Rnd,RhoU,RhoBTBandMiro) of thirtyRho GTPasegenes in three bivalve species, including nine in the Yesso scallopPatinopecten yessoensis, nine in the Zhikong scallopChlamys farreri, and twelve in ...
View and buy high purity Miro1 Reducer. Promotes mitochondrial Rho GTPase 1 (Miro1) degradation. Cited in 1 publication.