It harbors a unique open reading frame comprising 675 nucleotides and an internal ribosome entry site, specifically the − 150-bp sequence upstream of the ATG start codon. These attributes confer on circ-EIF6 the capacity to encode the protein EIF6-224aa. Notably, EIF6-224aa impedes the...
Circ Cardiovasc Qual Outcomes. 2013;6:157–63. Article PubMed Google Scholar Mattei da Silva ÂT, de Fátima Mantovani M, Castanho Moreira R, Perez Arthur J, Molina de Souza R. Nursing case management for people with hypertension in primary health care: A randomized controlled trial. Res ...
R2C Leydig tumor cells, which constitutively secrete large amounts of steroids, also show extremely high basal levels of SR-B1 protein and mRNA levels, and cAMP treatment modestly increases their levels further (86). It is becoming clear that the physical form of SR-B1 also plays a key ...
into the limelight. Methylated histones are recognized by proteins with methyl-binding domains [21,100]. Functionally, as the most common protein modification, it can affect cell fate in ways other than just at the transcriptome or protein level [101]. Histone methylation can potentially repress o...
Rassam P, Copeland NA, Birkholz O, Tóth C, Chavent M, Duncan AL, Cross SJ, Housden NG, Kaminska R, Seger U, et al: Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria. Nature. 523:333–336. 2015.PubMed/NCBIView Article:Google Scholar ...
of repeating sugar units. This fluctuation hinders the establishment of a focused immunological response, which aids the bacterium in evading the host immune system. The O-antigen also provides resistance to complement-mediated lysis, as it can interfere with the binding of complement proteins [65]...
Program Associate, Research Synthesis and New Technology, PCORI; and RTI International staff Eva Chang, PhD, Research Associate; Valerie Ng, BS, Research Assistant; Sharon Barrell, MA, Editor; Teyonna Downing, Publications Specialist; and Candi Wines, MPH, and Carol Woodell, BSPH, Program Managers...
20. Ng ACT, Delgado V, Borlaug BA, Diabesity: The combined burden of obesity and diabetes on heart disease and the role of imaging: Nat Rev Cardiol, 2021; 18; 291-304 21. Diaz-Canestro C, Xu A, Impact of different adipose depots on cardiovascular disease: J Cardiovasc Pharmacol, 2021;...
Nitroglycerin (NTG) is a prodrug that has long been used in clinical practice for the treatment of angina pectoris. The biotransformation of NTG and subsequent release of nitric oxide (NO) is responsible for its vasodilatating property. Because of the re
Obstructive Sleep Apnea (OSA) and hypertension have a high rate of co-occurrence, with OSA being a causative factor for hypertension. Sympathetic activity due to intermittent hypoxia and/or fragmented sleep is the most important mechanisms triggering the