In the context of clinical research, there is an increasing need for new study designs that help to incorporate already available data. With the help of historical controls, the existing information can be utilized to support the new study design, but of
the microchamber allows for the placement of oocytes in the side wells, serving as a repository for these critical cells. This initiated the application of microfluidics for gamete separation and processing, fertilization, and embryo culture to study in vitro fertilization and simulate the...
The most important limitation of our study is that we used a different methodology to obtain quality of life estimates in the validation study, compared to the original study. As discussed above, this might have led to systematically different quality of life estimates. Nevertheless, the most rele...
The Coriell Personalized Medicine Collaborative has devel- oped a methodology and format for return, differentiating risks based on genetic and nongenetic factors.106 Both the REVEAL Study (focusing on apolipoprotein E and the risk of Alzheimer disease) and ClinSeq (focusing on atherosclerotic disease)...
We then followed the methodology used by the Children’s Arthritis PSP in the Netherlands [15]. We had seven envelopes, each containing questions on a different topic. In total there were 31 questions—24 summary questions from the children’s surveys (Table 2), plus the seven new questions...
Virtual Reality in mental health treatment has potential to address a wide spectrum of psychological and neurocognitive disorders. Despite the proven benefits, integration into clinical practice faces significant challenges. There is a critical need for
Since the late 19th century, genital modifications (female and male) have been an important research subject in anthropology. According to a comparative and constructivist perspective, they were first interpreted as rites of passage, then as rites of ins
Our methodology is based on substantial and carefully planned primary research (qualitative study, ranking, and rating surveys) in addition to secondary literature, following best practices recommended in low-income settings [20], making sure that all included features are pertinent and applicable. Thi...
Use of systems thinking and adapted group model building methods to understand patterns of technology use among older adults with type 1 diabetes: a preliminary process evaluation Anna R. Kahkoska, Cambray Smith, Laura A. Young & Kristen Hassmiller Lich BMC Medical Research Methodology volume 24...
This study was a systematic review. Before it was conducted, a priori protocol for the research was registered in PROSPERO with registration identification number CRD42023440170. The methodology used in this review was based on the Cochrane Handbook for Systematic Reviews of Interventions [50] and Th...