Alzheimer's disease is a progressive neurodegenerative disease that impairs memory and cognitive judgment and is often accompanied by mood swings, disorientation and eventually delirium. It is the most common cause of dementia. Featured The Clinical Dementia Rating scale is useful but caution is needed...
Gregor Stein Janine S. Aly Olivia Engmann ArticleOpen Access21 Oct 2024 Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator Francesca Mandino Xilin Shen Evelyn M. R. Lake ArticleOpen Access18 Oct 2024 Neuronal alteration...
The field of Alzheimer's disease therapeutic research seems poised to bring to clinic the next generation of treatments, moving beyond symptomatic benefits to modification of the underlying neurobiology of the disease. But a series of recent trials has had disappointingly negative results that raise qu...
Better cellular models of Alzheimer's disease? For many years the lack of truly faithful cellular and animal models of AD has imposed some limitation on what can be inferred from these experimental models. With the technological advances demonstrating that human fibroblasts can be converted into plur...
A multimodal approach to slow Alzheimer’s progression with our AMBAR® Procedure: Alzheimer Management by Albumin Replacement
Alzheimer's disease was the eighth-leading cause of death in 2001. There is no cure and no effective treatment. Alzheimer's disease presents policy-makers with several challenges, including the level of funding and direction of federally funded research, as well as the cost pressures on Medicare...
participants were instructed to signal the experimenter whenever they felt comfortable enough with Protégé. Once the self-learning phase was over, participants were given the two main questionnaires and tasked to answer questions about Alzheimer’s disease with the help of ontology. Finally, participan...
Before PET scanning, Jagust says, researchers already knew from autopsies that about a third of older people with amyloid plaques had no symptoms of cognitive decline. "This created the argument: 'If they have no symptoms, how can it be that amyloid causes Alzheimer's?' You can't answer ...
A large number of clinical studies have proven that activated microglia play a dominant role in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis [97]. However, under pathological conditions (such as cerebral ischemia), activated ...