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Oct4andNanog. Additional HDACs likeHDAC1andHDAC6were also depleted as they were shown to have a role in self-renewal in embryonic stem cells and regulation of Sox2 in cancer respectively29,30. Depletion of
It should be noted that cell fusions may also give rise to polyploidy [36] or perhaps the parasexual events represent an intermediate step in the process of reversing tumour cell polyploidy, however their importance and sequence in this process is unclear. Similarly, although the means and cons...