Cell adhesion to the extracellular matrix regulates many fundamental aspects of cellular behaviour, including cell survival, proliferation, differentiation, and migration. Cell-matrix interactions are mediated by integrin-associated adhesion complexes, multiprotein complexes of intracellular scaffolding and ...
Matrix regulation of cell shape and gene expression Departments J.A. McDonald of Internal Medicine and Biochemistry, Washington St Louis, Missouri, USA University School of Medicine, Current Opinion in Cell Biology 1989, 1:995-999 Introduction The extracellular matrix of multicellular organisms is ...
Re-examining cell-matrix adhesion reveals reticular adhesions, a new class of adhesion. These αVβ5 integrin-mediated adhesions also lack conventional focal adhesion components and anchor mitotic cells to the extracellular matrix. As reviewed here, these studies present insight into how adhesion ...
It has long been proposed that the cell cycle is regulated by physical forces at the cell–cell and cell–extracellular matrix (ECM) interfaces1,2,3,4,5,6,7,8,9,10,11,12. However, the evolution of these forces during the cycle has never been measured in a tissue, and whether this ...
The stiffness and nanotopographical characteristics of the extracellular matrix (ECM) influence numerous developmental, physiological, and pathological processes in vivo. These biophysical cues have therefore been applied to modulate almost all aspects of cell behavior, from cell adhesion and spreading to ...
Metabolism and mechanics are intrinsically intertwined. External forces, sensed through the cytoskeleton or distortion of the cell and organelles, induce metabolic changes in the cell. The resulting changes in metabolism, in turn, feed back to regulate e
Cell-to-cell and cell-to-extracellular matrix (ECM) interactions in the functions of cell adhesion and signal transduction are important in global control ... Z Lin,W Zhang - 《Chinese Science Bulletin》 被引量: 5发表: 1999年 Nanoscale Control of Cell Behavior on Biointerfaces Understanding the...
PURPOSE OF REVIEW: Cellular functions like proliferation, differentiation, migration, morphogenesis and apoptosis are modulated by the extracellular matrix... SM Blattner,M Kretzler - 《Current Opinion in Nephrology & Hypertension》 被引量: 133发表: 2005年 HSP27 regulates cell adhesion and invasion ...
functions: AmrZ down-regulates motility and up-regulates putative extracellular matrix (ECM) components production whereas FleQ up-regulates motility and down-regulates putative ECM components production6. A similar antagonistic role of both TFs has also been shown by RNA-Seq during rhizosphere ...
This enables cells to generate traction during migration and exert tension during matrix remodeling (1). Cytoskeletal linkages also enable integrins to mediate cell adhesion and regulate cell shape and gene expression (1). Here we will summarize the evidence for direct interactions between integrin ...