Almost all the cells of the body apart from those of the liver and brain present some barrier to the entry of glucose from the blood. Many of the hormones act by altering the effectiveness of this barrier so changing the ease with which the glucose can enter the cells. Cells of the ...
Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance health and improve quality of life for people with type 1 and type 2 diabetes with reduced β-cell function. However, insulin delivery systems with rapid i
In addition, in INS-1E cells, knockdown of syt-9 had no effect on basal insulin release, but reduced glucose-stimulated secretion of insulin by 69% (ref. 21); however, changes in insulin secretion were not detected in in vivo studies22. However, in PC12 cells, it is well-established ...
Under r M these conditions, a very small pool of granules is present at the plasma membrane and a n primed to release insulin in response to an increase in blood glucose levels. When feeding u s induces glucose uptake by β-cells, further granules are trafficked through the secretory c r...
Ultrasound-Triggered Regulation of Blood Glucose Levels Using Injectable Nano-Network The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vit... J Di,J Price,X Gu,... - 《Advanced Healthcare ...
Modern medicine emphasizes the concept of homeostasis, constancy of the intern milieu. Accordingly, it is assumed that biological functions and processes are relatively stable during the 24 h and other time periods and that the exacerbation of disease an
6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxane-2,4,5-triol (SID 242078875) was isolated from the fruits of Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae), which has been traditionally used in the treatment of diabetes by the...
The results obtained suggest that glucose-sensitive vagal afferents from the liver play an important role in the control of food intake as well as in the control of blood glucose levels. 展开 关键词: liver glucose-sensitive nerve fibers food intake guinea pig ...
First, the blood–blood barrier, which partitions the circulating blood from the CNS, acts as a gatekeeper to facilitate the selective trafficking of substances between the blood and the parenchyma. Second, neurovascular coupling ensures that, following local neural activation, regional blood flow is ...
Under fasting conditions, the liver has a major role in generating glucose as a fuel for other tissues, such as the brain, red blood cells and muscles. Initially, an increase in the pancreatic hormone glucagon initiates the cascade of kinase action (stated below in detail) that releases glucos...