We should note that prior to the ICH E6 update, both the FDA and EMA had already provided strong endorsements to move towards RBM and RBQM--in the form of guidance documents that were finalized in 2012. Risk-Based Monitoring: Leveraging intelligent analytics to realize the full value of RBx...
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RNA–binding motif protein 24 (RBM24) acts as a multifunctional determinant of cell fate, proliferation, apoptosis, and differentiation during development by regulating premRNA splicing and mRNA stability. It is also implicated in carcinogenesis, but the
Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated i
Full size image Omicron spike maintains the one-RBD-up conformation after ACE2 binding Previous data revealed that the spike undergoes conformational alteration by the rigid-body rotation of the RBD with a smaller conformational change in other domains of S1 components upon ACE2 binding29,30. The...
Full size image Ahnak mRNA contains a miR-222-binding site in the coding region, whereas Rbm24 mRNA contains two miR-222-binding sites in the 3’UTR (Rb-1 and Rb-2), the most downstream (Rb-2) being that found by RNA sequencing. To show that miR-222 directly regulates the expression...
Wieland Schönfelder creates 3D-printed sculptures that bring to mind otherworldly realms. Through their simple and formal construction, they structure, arrange and move through the room. He was born in 1985 in Berlin, where he lives and works. Selected exhibitions includeThey Are Waiting For The...
Full size image MAGOH binding disrupts nucleolar localization Full size image References Download references Acknowledgements This work was supported by Kanazawa Medical University (S2015-11, C2015-1), Ministry of Education, Culture, Sports, Science and Technology Japan and a Grant-in-Aid for Scientif...