RATIONALE 304为一项在中国人群中开展的替雷利珠单抗联合化疗一线治疗非鳞NSCLC的关键III期临床研究,共纳入334名IIIB及IV期非鳞NSCLC患者,采用了2:1比例的随机分组,试验组为替雷利珠单抗联合铂类+培美曲塞(A组,n=223),对照组为单纯标准化疗(B组,n=111),预设的分层因素包含了疾病分期和PD-L1表达水平这两个可能...
除了在晚期NSCLC后线治疗的RATIONALE 303研究,替雷利珠单抗在非鳞NSCLC一线治疗(RATIONALE 304研究),鳞状NSCLC一线治疗(RATIONALE 307),NSCLC围手术期治疗(RATIONALE 315)以及小细胞肺癌一线治疗(BGB-A317-312研究)中均有III期研究开展。五大研...
RATIONALE 304研究是上海交通大学附属胸科医院陆舜教授领衔开展的一项随机III期临床研究。在之前的II期RATIONALE 206研究中,免疫疗法联合化疗显著延长了患者的PFS,提高了缓解率。在此基础上,RATIONALE 304研究比较了替雷利珠单抗联合培美曲塞和铂类方案,对比培美曲塞联合铂类方...
此前RATIONALE-307、RATIONALE-304、RATIONALE-303三项晚期NSCLC的Ⅲ期研究均获得成功,替雷利珠单抗在晚期NSCLC实现了全线全人群获益、独家适应症及医保全面覆盖,并通过RATIONALE-312研究将获益人群从NSCLC进一步拓展到了SCLC。RATIONALE-315研究的成功更是让替雷利珠单抗成为全球唯一实现肺癌免疫治疗从晚期到早期全人群获益大...
2015;27:304–10. Google Scholar Taylor RW, Gold E, Manning P, Goulding A. Gender differences in body fat content are present well before puberty. Int J Obes Relat Metab Disord J Int Assoc Study Obes. 1997;21:1082–4. CAS Google Scholar Lindsay AC, Sussner KM, Kim J, Gortmaker S...
Study Type 鈥 Prognosis (case series)Level of Evidence 4What's known on the subject? and What does the study add?Epigenetic alterations play an essential r... AC Schneider,LC Heukamp,S Rogenhofer,... - 《Bju International》 被引量: 99发表: 2011年 Re: defining progression in nonmuscle ...
See: Karlyn Kohrs Campbell, "Stanton's `Solitude of Self': A Rationale for Feminism," Quarterly Journal of Speech 66 (1980): 304‐312; Karlyn Kohrs Campbell, "The Humanistic Underpinnings of Feminism: `The Solitude...
With a median study follow-up of 9.8 months, PFS was significantly longer with tislelizumab plus chemotherapy compared with chemotherapy alone (median PFS: 9.7 versus 7.6 months; HR=0.645 [95% CI: 0.462, 0.902]; P=0.0044). Additionally, response rates were higher and response duration was ...
BMC Public Health (2016) 16:304 DOI 10.1186/s12889-016-2971-7 STUDY PROTOCOL Open Access Rationale and design of a randomized controlled trial examining the effect of classroom-based physical activity on math achievement Mona Have1*, Jacob Have Nielsen1, Anne Kær Gejl1, Martin Thomsen ...
Retaining teeth in their corrected positions following orthodontic treatment is one of the most challenging aspects of orthodontic practice. Despite much research, the rationale for retention is not entirely clear. Teeth tend to revert to their pre-treatment positions due to periodontal and gingival, ...