TGF-β1 is generally released in a biologically latent form (L-TGF-β1). Before being biologically active, TGF-β must be converted to its active form and interact with both TGF-β receptors type I and II (TβR-I and TβR-II). TGF-β latency binding protein 1 (LTBP-1), which ...
Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis. Khalil N,Parekh T V,O’Connor R,Antman N,Kepron W,Yehaulaeshet T,Xu Y D,Gold L I. Thorax...
Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) i... BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is characterised by subpleural fibrosis that progresses to involve all areas of ...
Macrophages treated with TGFβ2 (TGFβ2-Mϕ) and antigen are highly tolerogenic in vivo, and induce antigen-specific and long-lasting tolerance in both naïve and primed mice via induction of suppressor/regulatory T cells. In this study, we examined the molecular pathways, including the requ...
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell. 1999;96(3):425–36. Article CAS PubMed Google Scholar Yadin D, Knaus P, Mueller TD. Structural insights into BMP receptors: specificity, activation and inhibition. Cytokine Growth ...
TGF-β 1-treated group. (d,e) Inhibition of autophagy by BECN1 siRNA decreased fibronection and collagen I α 2 biosynthesis. BECN1 knocked down cells and their correspondence scramble infected cells were treated with TGF-β 1 (10 ng/ml) for 48 and 72 hours. Protein ...
PREPARATION:A blood platelet is reacted with thrombin to secrete a latent TGF-beta and a supernatant containing the latent TGF-beta is separated from a precipitated blood platelet aggregate. Then the supernatant is concentrated according an ordinal method, dialyzed by a phosphoric acid buffer ...
Overcoming the hurdles in using mouse genetic models that block TGF-β signaling The recent recognition of the importance of transforming growth factor beta (TGF-β) in mediating many cellular immune functions has popularized the use of... SRA Flavell - 《Journal of Immunological Methods》 被引量...
目的 探讨细胞中富亮氨酸糖蛋白(LRG)高表达对转化生长因子β1(TGF-β1),转化生长因子受体体II(TβR-II)的影响.方法 设计构建pAcGFP1-C1-LRG质粒,设为转染组和对照组,转染组将pAcGFP1-C1-LRG质粒转染入U87脑胶质瘤细胞,分别于转染后48 h及72 h收集细胞,提取总RNA,应用Real-time PCR方法 测定U87细胞中LRG...
TNFSF13B ProteinHuman重组小鼠 Inhibin beta A / INHBA / Activin A 蛋白 (His 标签) TNFSF13B ProteinCynomolgus重组小鼠 Interleukin-2 / IL-2 蛋白 TNFSF13B ProteinMouse重组小鼠 Latent TGF-beta 1 / TGFB1 蛋白 (His 标签) TNFSF13B ProteinMouse重组小鼠 LIF 蛋白 (Fc 标签) TNFSF15 ProteinRat重组...