The one-pot, three-component reaction is also reported to take place rapidly using water as solvent <2004M589>. (62) 10.06.9.2.5 Thienopyrans Thiopyranones containing an alkyne group, upon treatment with m-chloroperbenzoic acid (MCPBA), undergo a sulfoxide rearrangement to afford thieno[3,...
The key for this reaction is thein situgeneration of a hypervalent iodine compound ArIF2by hydrogen fluoride,mCPBA and a catalytic amount of iodoarene. Preliminary trials of catalytic asymmetric nucleophilic fluorination were conducted.doi:10.1002/chin.201451042...
Methylsulfinylimidazopyridine derivative (7) obtained by the reaction of 5b with m-chloroperbenzoic acid (m-CPBA), easily underwent nucleophilic substitution to give the corresponding substituted compounds (8a-e). The substitution of chloroimidazopyridine derivative (11) with nucleophiles produced the ...
19 The pyridine N-oxide 2 was obtained using meta-chloroperoxybenzoic acid (mCPBA) to perform an N-oxidation reaction. The cyano group was introduced on the pyridine ring under trimethylsilyl cyanide (TMS-CN) to give cyanide intermediate 3, which was then converted to amide 4 by hydration ...
-5-nitro-1H-benzimidazoles 3a-3b were synthesized by coupling 1-methyl-2-mercapto-5-nitro-1H-benzimidazole 1 with various pyridine derivatives 2a-2b in the presence of a base at room temperature, Upon further oxidation of these Benzimidazole derivatives 3a-3b in presence of MCPBA gives 1-...
7-Isopropyl-1,3-dimethyl-1H-pyrazolo[4,3-b]pyridine 4-oxide: To 7-isopropyl-1,3-dimethyl-1H-pyrazolo[4,3-b]pyridine (prepared in the previous step, 2.50 g, 13.22 mmol) in 100 mL of chloroform was added 77% MCPBA (5.91 g, 26.44 mmol) at 0° C. The resulting solution was stirr...
Referring to Scheme 3, oxidation of compound 4 can be achieved by a range of standard oxidising agents such as oxone or mCPBA in a solvent such as acetonitrile or dichloromethane reaction of compound 5 with compound 6 may be carried as described in Scheme Ito provide compound 7. The couplin...
Toshifumi DohiDep. Front. Mater.Yasuyuki KitaDep. Front. Mater.Norio ShibataDep. Front. Mater.ChemInformSuzuki S, Kamo T, Fukushi K, et al. Iodoarene-catalyzed fluorination and aminofluorination by an Ar-I/HF.pyridine/mCPBA system. Chem Sci. 2014;5(7):2754-2760....
m-CPBAammoniaAn improved, safe, and scalable isolation process for (substituted) pyridine and quinoline N-oxides in quantitative yields along with high purities using the m-CPBA-NH3(g) system is described. The safety was assessed by reaction calorimetry and differential scanning calorimetry studies ...
Oxidation of this O-Boc-protected pyridine derivative with m-chloroperbenzoic acid (m-CPBA, 1.4 equivalents) quantitatively furnished N-oxide 20 which was subsequently treated with trifluoroacetic anhydride to promote a Polonovski-Potier reaction.[21] Addition of lithium hydroxide to the mixture ...