PUM2CXCR4RNA Binding ProteinProliferationThe aim of the present study was to investigate the mechanism by which pumilio RNA binding family member 2 (PUM2), an RNA-binding protein (RBP) of C-X-C chemokine receptor type 4 (CXCR4), exerts its effects on the development of lung cancer. RT-...
蛋白别名:HsPUM; pumilio 1; Pumilio homolog 1; pumilio RNA-binding family member 1; pumilio-1 基因别名:AA517475; HSPUM; KIAA0099; mKIAA0099; PUM1; PUMH; PUMH1; PUML1; Pumm UniProt ID:(Human) Q14671,(Mouse) Q80U78 Entrez Gene ID:(Human) 9698,(Mouse) 80912 ...
The intracellular localization, stability and translation of mRNAs is regulated by interaction of RNA-binding proteins (RBPs) or microRNAs with specific sequences present in the 3′ untranslated regions (3′UTR) of the mRNA9,10,11. In budding yeast, the 3′UTR of the Xbp1-orthologue Hac1 ta...
Pumilio is the founding member of the PUF-family RNA-binding factors, and recognizes highly conserved Pumilio Response Elements (PREs) of a “UGUAAAU” consensus (Chen et al., 2012). From:Current Topics in Developmental Biology,2015 Discover other topics ...
Article: Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins
We used mutagenesis and RNA-Clip to show that Pum1 regulates Atxn1 levels by binding directly to the highly conserved motif in its 3′ UTR. Pum1 is a member of a well-characterized family of RBPs, known as the PUF family, which are involved in various physiological processes (Spassov ...
organonitrogen compound metabolic process. The gene ontology categories are localized in multiple cell compartments, from the cytoplasm to pigment granules, vesicles and the endoplasmic reticulum. Over-represented molecular functions included: RNA binding, oxidoreductase activity, protein binding, organic ...
PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. It is a member of the PUF family comprised of evolutionarily conserved RNA-binding proteins. PUM1 binds to an RNA consensus sequence, the...
1998. Here we present the structure of the HsPUM-HD in complex with NRE RNA. Our studies reveal how this family of RNA binding proteins interacts with RNA. The structure confirms earlier predictions that the RNA would be bound to the concave surface of the protein. Surprisingly, the ...
Here, we demonstrate that ESAG8 interacts with a member of the Puf family of RNA regulatory proteins, which we named PUF1. An epitope-tagged version of PUF1 is cytoplasmic when over expressed, suggesting that ESAG8 has a function that may be distinct from any role in ES transcription. ...