SCLCsurvivalDeltex(DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early﹕tage non﹕mall cell lung cancer (NSCLC), in 261 patients with small cell lung...
Visceral pleural invasion (VPI) is an adverse prognostic factor in non‐small cell lung cancer (NSCLC); however, its effect in relation to tumor size remains under debate. To better understand the prognostic impact and potential consequences for staging, we examined correlations betweenVPIand clinic...
In the younger group, SCLC was the second most common pathological type, but it ranked third in the older group (24.67% vs 14.29%). There were no statistically significant differences in either tumour sites or subsites between the groups (Table 2). The distribution of stages was significantly...
Lung cancer is broadly categorized as non-small cell lung cancer (NSCLC), making up around 85% of cases. Small cell lung cancer (SCLC) contributes to 15% of cases and includes a few histological sorts, like adenocarcinoma, large cell carcinoma, and squamous cell carcinoma (Lehtiö and De...
Despite progression in surgery and chemotherapy, prognosis of SCLC remains unfortunately extremely bad, and new therapeutic approaches would be hoped for. In this sense, the finding of new biologic factors related to progression and poor outcome may represent a useful target of innovative thera- peut...
the occurrence of lung cancer is influenced by diverse factors, including genetic damage to DNA and some epigenetic changes, mainly caused by smoking and air pollution.3,4 Two major subtypes are included in lung cancer: small-cell lung cancer (SCLC) and non-small- cell lung cancer (NSCLC)....
Small-cell lung cancer (SCLC)Poor pulmonary function and chronic obstructive pulmonary disease (COPD) are associated with poorer overall survival (OS) in non-small-cell lung cancer (NSCLC) patients. Few studies have investigated the association between pulmonary function and OS in small-cell lung ...
Advance disease (AD) was defined as patients with Stage IV non-small cell lung cancer (NSCLC) or extensive stage small cell lung cancer (SCLC), and non-advanced disease (non-AD) was defined as ≤Stage III NSCLC or limited stage SCLC. Results Out of 727 patients included in our review,...
In lung cancers, point mutations of the p53 gene have been found in all histological types including approximately 45% of resected NSCLC and even more frequently in SCLC specimens. Mutant forms of the p53 protein have transforming activity and interfere with the cell-cycle regulatory function of ...
the occurrence of lung cancer is influenced by diverse factors, including genetic damage to DNA and some epigenetic changes, mainly caused by smoking and air pollution.3,4 Two major subtypes are included in lung cancer: small-cell lung cancer (SCLC) and non-small- cell lung cancer (NSCLC)....