Fig. 1: Transcriptional profiling by bulk RNA-seq to investigate the sex-dependent microglial aging process and ADEM gene set. a, Scheme of timepoints for microglia bulk RNA-seq analysis. Microglia were collected by FACS from C57BL/6J female and male mouse brains. b,c, Heat maps of microgl...
The process is characterized by: knocking off the prion protein gene of domestic animals on a cellular level; and preparing prion protein gene knockout domestic animals through somatic cell cloning method. The function of the prion protein of domestic animals is inactivated. The functional prion ...
The production of N-linked glycoproteins in genetically amenable bacterial hosts offers great potential for reduced cost, faster/simpler bioprocesses, greater customisation, and utility for distributed manufacturing of glycoconjugate vaccines and glycoprotein therapeutics. Efforts to optimize production hosts have...
mRNAs transmit the genetic information that dictates protein production and are a nexus for numerous pathways that regulate gene expression. The prevailing view of canonical mRNA decay is that it is mediated by deadenylation and decapping followed by exonucleolysis from the 3′ and 5′ ends. By ...
Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. J Neurosci. 1999;19(10):4110–22. Article CAS PubMed PubMed Central Google Scholar Routtenberg A. Reverse piedpiperase: is the knockout mouse leading neuroscientists to a watery end?
This protein is one of the 17 essential subunits that contribute to the complete assembly of 20S proteasome complex [42]. Fig. 3 Scheme of proteasome pathway. The up-regulated transcripts in the Bmfib-H gene knock-out PSG are indicated by a red frame Full size image When abnormal proteins...
mammalian mitochondrial gene expression, highlights key questions and indicates how defects in this process can result in profound mitochondrial disease. Introduction Mitochondria are organelles that perform several different functions crucial for the homeostasis of most eukaryotic cells. The suggestion has ...
gene silencing mediated by short double-stranded RNA molecules called small interfereing RNAs (siRNA). In mammalian cells, transfection of 21-22 nucleotide siRNAs leads to degradation of mRNA molecules that contain the same sequence as the siRNA. In the ...
aData from gene knockout models and pharmacologic experimentssuggest that MMPs may be attractive therapeutic targets forstroke. 数据从基因MMPs也许是有吸引力的治疗目标forstroke的击倒模型和药物experimentssuggest。[translate] aunderpass Exit;t 地下过道出口; 隧道出口[translate] ...
2.The process of claim 1, wherein the genetic modification treatment includes the sequential steps of:deleting, disrupting, or disabling the fps1 gene in the genome of the parent yeast cell;introducing the second gene encoding XDH into the genome of the parent yeast cell for over-production o...