The NOS inhibitor, L-NAME, reduced 15d-PGJ2 mediated NO production and attenuated 15d-PGJ2 repression of TNFa mediated ICAM expression. Conclusions These data indicate that treatment with 15d-PGJ2 suppressed TNFa-stimulated expression of inflammatory genes in vascular endothelial cells. L-NAME-...
The effect of 15d-PGJ2, and glitazones was analyzed on various prostate carcinoma cells which were stimulated with either VEGF, EGF, HGF, IGF, TNF, SEB, C5a for 5- to 48 hours. As bacterial stimuli were chosen (n=5) or i (n=5)....
15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. J Biol Chem 2003, 278: 14747–14752. Article PubMed CAS Google Scholar Yan S, Zhou C, Zhang W, Zhang G, Zhao X, Yang S, et...
Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. The cyclopentenone prostaglandin (cPG) 15-deoxy-螖 12,14 -PGJ 2 (15d-PGJ 2 ) has been identified as a potent antiinflammatory agent that is...
[148]. TZDs decrease COX-2, inhibit growth of non-small-cell lung cancer cells in vitro, and block tumor development. TZDs diminish COX-2 and PGE2 through PPAR gamma. The PPAR gamma activator 15dPGJ2 plays an anti-inflammatory role in a PPAR gamma-dependent manner, decreasing COX-2, ...
15d-PGJ2 Primes Eotaxin-induced Eosinophil Chemotaxis Through PPAR-Gamma Ligationdoi:10.1016/j.jaci.2005.12.237S. Ueki and Y. Kobayashi and G. Mahemuti and T. Chiba and N. Saito and A. Kanda and H. Kayaba and K. Ohta and J. Chihara...
They did not require the engagement of peroxisome proliferator-activated receptor gamma (PPAR gamma), since the response to 15d-PGJ2 was neither mimicked by the PPAR gamma agonist ciglitazoneScientific Committee: L. BaudF. BerenbaumC. Brink...
Administration of the PPAR-gamma ligand, 15d-PGJ2, down-regulates the immune response to injury and improves survival after septic challenge in a murine trauma modelTRAUMAIMMUNOLOGYPPAR-GAMMAMACROPHAGENITRIC OXIDECECAL LIGATIONTwo nine-year runs of the NCAR Community Climate Model (Ver. 3) are ...
downregulation, markedly lowering the expression of TLR4 and TLR2. In vitro, both rosiglitazone and 15d-PGJ2 inhibited CS-induced inflammation through the TLR4 signaling pathway. Conclusions These results suggest that PPAR?? agonists regulate inflammation in alveolar macrophages and may play a role in...
PEROXISOME PROLIFERATOR ACTIVATOR RECEPTOR-[gamma] (PPAR[gamma]) LIGANDS, 15-DEOXY-[DELTA]12,14- PGJ2 (15D-PGJ2) AND CIGLITAZONE, PROVIDE CARDIOPROTECTION DURING REPERFUSION THROUGH DIFFERENT MOLECULAR MECHANISMS.: 184An abstract is unavailable. This article is available as a PDF ...