Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue. ...
McKay, et al., Upregulation of proteolytic pathways and altered protein biosynthesis underlie retinal pathology in a mouse model of Alzheimer’s disease. Mol. Neurobiol. 56(9), 6017–6034 (2019). https://doi.org/10.1007/s12035-019-1479-4 Article PubMed CAS Google Scholar Y. Liu, L. ...
Canine distemper is a fatal disease in dogs, caused by a single-stranded, negative-sense RNA virus of the genusMorbillivirus, which is closely related to the human measles virus. The canine distemper virus (CDV) host range includes dogs and other canids, as well as ferrets, raccoons, bears,...
Availability of data and materials This is a narrative review based on published data. Abbreviations AD: Alzheimer’s disease APC: Anaphase-promoting complex ATOX1: Antioxidant 1 ATP7A: ATPase copper transporting alpha ATP7B: ATPase copper transporting beta CCO: Cytochrome c oxidase CCS: ...
Neurodegenerative diseases, in particular, Alzheimer’s disease (AD), represent a prominent social and medical problem, because of the progressively increasing number of patients, considerable economic losses associated with medical attendance, and the lack of effective therapy1,2,3. The drugs used cur...
HUC–MSCs are still used mainly in regenerative medicine for liver cell therapies, in the treatment of autism, type 1 and type 2 diabetes, stroke, spinal cord and brain injuries, Parkinson's and Alzheimer's disease, and multiple sclerosis. Clinical studies are currently investigating their potent...
Elan is developing AN-1792 as a potential immunotherapy for Alzheimer's disease (AD). It is currently in phase I trials [350904]. Phase II/III trials, running in parallel in the US and UK, are expected to start by the end of 2001 [375061], [383226], [401966]. American Home ...
The ability to control the transition from an undifferentiated stem cell to a specific cell fate is one of the key techniques that are required for the app
we summarize the current knowledge on molecular and circadian regulatory mechanisms of melatonin to overcome neurodegenerative diseases (NDDs) such as Alzheimer’s, Parkinson’s, Huntington’s disease, and amyotrophic lateral sclerosis, however, these findings need to be confirmed by larger, well-designe...
Neurodegenerative diseases, in particular, Alzheimer's disease (AD), represent a prominent social and medical problem, because of the progressively increasing number of patients, considerable economic losses associated with medical attendance, and the lack of effective therapy1–3. The drugs used ...