Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; ho
Alzheimer's disease (AD) is the common cause of dementia with huge implications for the elderly. This slowly progressive neurodegenerative disease is currently becoming a global health crisis that lacks effective treatment [1,2]. Memory decline, neuropsychiatric symptoms, and cognitive dysfunction are ...
7 Mitophagy defects have also been described in preclinical models of Alzheimer’s disease (AD), postmortem tissue of AD patients, and in the central nervous system (CNS) and platelets of patients with Parkinson’s disease (PD). Similarly, swollen and dysfunctional mitochondria were found in the...
Gonzales MM, Garbarino VR, Marques ZE, Petersen RC, Kirkland JL, Tchkonia T, Musi N, Seshadri S, Craft S, Orr ME (2022) Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD): a Pilot Clinical Trial. J Prev Alzheimers Dis 9:22–29. https://doi.org/10.14283...
Alzheimer’s disease is neurodegenerative disorder due to the accumulation of amyloid-β in the brain and causes dementia with ageing. Some researches indicate that the RXR agonist, Targretin, has also been used for treatment of Alzheimer’s disease in mouse models. We investigate the potent cand...
2. Infection leads to fatal systemic disease with a variety of clinical signs such as respiratory and gastrointestinal disorders, skin alterations and severe immunosuppression, which favors secondary infections. In the central nervous system (CNS), infection causes demyelinating leukoencephalitis (CDV-DL)...
Neurodegenerative diseases, in particular, Alzheimer’s disease (AD), represent a prominent social and medical problem, because of the progressively increasing number of patients, considerable economic losses associated with medical attendance, and the lack of effective therapy1,2,3. The drugs used cur...
Thioredoxins Availability of data and materials This is a narrative review based on published data. Abbreviations AD: Alzheimer’s disease APC: Anaphase-promoting complex ATOX1: Antioxidant 1 ATP7A: ATPase copper transporting alpha ATP7B: ATPase copper transporting beta ...
HUC–MSCs are still used mainly in regenerative medicine for liver cell therapies, in the treatment of autism, type 1 and type 2 diabetes, stroke, spinal cord and brain injuries, Parkinson's and Alzheimer's disease, and multiple sclerosis. Clinical studies are currently investigating their potent...
From circadian sleep disruption to Neuroprotection: The potential of VIP/PACAP in Alzheimer’s disease treatment Author links open overlay panelArtur Galushkin, Illana GozesShow more Add to Mendeley Share Cite https://doi.org/10.1016/j.crbiot.2024.100254Get rights and content...