A case of CD5-positive mature B-cell neoplasm with t(10;14)(q24;q11.2) and trisomy 12The translocation t(10;14)(q24;q11.2) is found in 5–10% of cases of T-cell acute lymphoblastic leukemia (T-ALL) [1,2]. The genes involved in t(10;14)(q24;q11.2) are the T-cell ...
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a B-cell neoplasm that is typically CD5 negative. We describe the clinicopathologic, immunophenotypic, and cytogenetic features of 14 cases of CD5+ MALT lymphoma. There were 9 men and 5 women (median age,...
One case was purely monomorphic diffuse large B-cell lymphoma. We show that this lymphoma type is a neoplasm with prominent classical and alternative nuclear factor-kB pathway activation in neoplastic cells (79% of the cases showed nuclear staining for p105/p50, 74% for p100/p52 and 63% for...
1 Montes-Moreno et al8 subdivided the polymorphic EBV-positive DLBCL of the elderly into 3 subgroups based on the relative proportion of large neoplastic cells and presence of HRS-like cells: (1) canonical large B-cell neoplasm (high density of large neoplastic cells and scattered cells with ...
The large cell-predominant pattern may mimic DLBCL in a subset of cases. These large transformed cells are partially positive for CD20 and exhibit PAX5, Oct-2, MUM1, CD30, and EBER positivity, but are CD10 and BCL6 negative with a non-germinal center immunophenotype. CD15 ...
CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Ima
The lymphoma consists of grade 3B (80–90%, a,b) and diffuse large B-cell lymphoma (10–20%, c,d). Immunostains show that the lymphoma cells are positive for CD20 (e), weakly positive for CD5 (f), and are negative for CD3 (g). An antibody for Ki-67 (MIB-1) shows that ~...
EBV is a herpesvirus with demonstrated B-cell lymphotropism. EBV infection starts by attachment of the virus to the CD21 antigen; this initial step prepares the B-lymphocyte for EBV infection and is characterized by increased production of IL-6 and mRNA along with blastic transformation and mobil...
lodged in the nasal mucosa, may induce local EBV-infected memory B cells to enter the lytic cycle and thereby transmit virus to locally activated T and/or NK cells. Persistent EBV infection is a risk factor for a wide range of human tumors and malignant diseases such as T/NK cell LPD. ...
In addition, FCM performed in PB, showed 3% CD45+low, CD117+, CD34+ MPC, and 21% of CD45+low, CD117+, CD34− MCP, which were phenotyp- ically similar to the correspondent BM cell populations, at least for the cell surface markers tested, but not CD45+, CD34−, and CD117+...