Population PK‐PD model for Fc‐osteoprotegerin in healthy postmenopausal women. J Pharmacokinet Pharmacodyn 35: 379‐399, 2008.Zierhut ML, Gastonguay MR, Martin SW, et al. Population PK-PD model for Fc- osteoprotegerin in healthy postmenopausal women....
To neutralize the effects of RANKL, the body naturally produces the protein osteoprotegerin (OPG), which acts as a decoy receptor for RANKL and contributes to bone homeostasis. We describe the piecewise development of a three-compartment pharmacokinetic model with both linear and Michaelis–Menten ...
The present study developed a population PK-PD model of subcutaneous PEG-IFN alfa-2a in a Korean population. For PK, IFN alfa-2a concentrations were described by a 1-compartment model with first-order absorption, preceded by skin-to-depot first-order input. For PD, serum 2'-5' oligo...
The problem of nuisance covariate model specification is considered in Cox regression where the maximum semiparametric likelihood method is used to handle ... YC Hua - 《Journal of the American Statistical Association》 被引量: 75发表: 2002年 The role of population PK–PD modelling in paediatric ...
KEY WORDS model evaluation . morphine . paediatric pharmacokinetic population modeling ABBREVIATIONS IQR inter quartile range M3G morphine-3-glucuronide M6G morphine-6-glucuronide MPE mean prediction error NPDE normalized prediction distribution error PD pharmacodynamics PK pharmacokinetics PMA postmenstrual age...
3) physiological PK/PD model 生理药动药效联合模型4) four basic attributes of PK/PD model 药动药效联合模型的四个属性 1. This paper recommends some new research progress including PK models, PD models, four basic attributes of PK/PD model, population PK/PD model , physiological PK/PD ...
Population modeling has become an important component of quantitative model-based drug development. In addition, PK/PD models can be important extensions of therapeutic drug management in infectious diseases. The concept of population model-based individualized antimicrobial therapy is described. With the ...
Load a model from the internal library mod<-mread("pk1", modlib()) Simulate a simple regimen mod%>% ev(amt=100,ii=24,addl=9) %>% mrgsim(end=300,delta=0.1) %>% plot(CP~time) A more complicated regimen: 100 mg infusions over 2 hours every 24 hours for one week, followed by...
–Modeling PD using differential equations mandates a functional form (model) for PK Joga Gobburu September 30, 2008 19 Introduction to Population Analysis Population mean versus Typical value • Population mean is the naïve overall mean of a parameter –For example, the population mean CL is...
Population PK/PD analysis of the pan-HDAC inhibitor resminostat Resminostat, an oral pan-HDAC inhibitor, was investigated in various oncological indications. To investigate pharmacokinetic (PK) and pharmacodynamic (PD) properties of resminostat, a population PK/PD model was established to quantitat...