The genome sequence of Aspergillus fumigatus revealed the presence of a single hybrid polyketide synthase鈥搉on-ribosomal peptide synthetase (PKS/NRPS) gene that is present within a cluster of five genes suggestive of its involvement in secondary metabolism. Here, we present evidence that it is ...
杂合NRPS-PKS的研究进展 Ⅰ型聚酮合酶(polyketide synthase,PKS)和非核糖体肽合成酶(nortfibosomal peptidesynthetase,NRPS)具有相似的结构和功能特点,它们都是具有模块结构的多功能的巨型酶... 连云阳,程元荣 - 全国创新药物及新品种研究, 开发学术研讨会 被引量: 5发表: 2006年 加载更多来源...
Bohnert, H.U. et al. A putative polyketide synthase peptide synthetase fromMagnaporthe griseasignals pathogen attack to resistant rice.Plant Cell16, 2499–2513 (2004). ArticleGoogle Scholar Gaffoor, I. et al. Functional analysis of the polyketide synthase genes in the filamentous fungusGibberella ...
Summary Mining the genome of the pathogenic fungus Aspergillus terreus revealed the presence of an orphan polyketide-nonribosomal-peptide synthetase (PKS-N... Markus,Gressler,and,... - 《Chemistry & Biology》 被引量: 110发表: 2011年 Bioactive compounds synthesized by non-ribosomal peptide synthetases...
ANALYZE HYBRID NRPS/PKS SEQUENCES 可进入 化合物快速分析界面,通过序列比对分析未知氨基酸 序列。点击 NRPSDB、PKSDB、ITERDB 和 CHSDB 链 接,分别进入相应子数据库界面[18]。 NRPSDB NRPSDB 数据库搜集了 17 个 NRP 簇和 5 个杂合 · 282 ·
Here, we report a fungal non- ribosomal peptide synthetase -polyketide synthase (NRPS-PKS) hybrid FnsA for the naringenin formation. Feeding experiments with isotope-labelled precursors demonstrate that FnsA accepts not only p-coumaric acid (p-CA), but also p-hydroxybenzoic acid (p-HBA) as ...
biosynthesis of amino acid derived pyrones by an nrps nrpks hybrid megasynthetase in fungi 来自 ACS 喜欢 0 阅读量: 9 作者: yanghai 摘要: Fig. S20. HMBC NMR spectrum of desacetyl-pyrophen (5) formate salt in (CD3)2SO (500 MHz). ...37 Fig. S21. 1H NMR spectrum of Boc-desmethyl-...
The ring structure of pyridomycin was generated by the nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) hybrid system (PyrE-PyrF-PyrG)... T Huang,Z Zhou,M Wei,... - 《Applied & Environmental Microbiology》 被引量: 0发表: 2022年 加载更多来源...
To establish the genetic bases for the biosynthesis of the mutagenic compound NG-391, we identified a 19,818聽kb genomic region harboring the predicted hybrid polyketide synthase-nonribosomal peptide synthetase NGS1, plus five additional ORFs. NGS1 knockouts generated by Agrobacterium-mediated ...
TeA is thought to be a hybrid of an isoleucine and two acetates12. Due to its tetramic acid-containing structure (Fig. 1a), TeA is also expected to be a product of a polyketide synthase and non-ribosomal peptide synthetase (PKS–NRPS) hybrid enzyme13. Typical fungal secondary metabolite ...