药物动力学/药效动力学(PK/PD)模型是定量药理学的核心内容之一,能够定量研究体内药物浓度、药物效应与时间的动态关系,并为保证新药研发和临床过程中药物的有效性和安全性提供了量化依据。 定量药理学研究的主流工具 ——NONMEM软件 定量药理学...
Utility of PK-PD Modeling and Simulation to Improve Decision Making for Antibody-Drug Conjugate Development. In Innovations for Next-Generation Antibody-Drug Conjugates Cancer Drug Discovery and Development; Damelin, M., Ed.; Humana Press: New York, NY, USA, 2018.Singh AP, Shin YG, Shah DK....
原文链接:https://www.certara.com/blog/modeling-and-simulation-optimizing-phase-3-study-design-to-obtain-fda-approval/ 建模和模拟(M&S)正在改变药物开发以及药物如何接受监管审查的方式。Certara公司旗下的Phoenix NLME和Trial Simulator等定量药理学相关软件利用动物试验和临床试验现有数据建模,通过模拟减少不确定性...
This example requires Statistics and Machine Learning Toolbox™. The performance can be improved if you have the Parallel Computing Toolbox™ software.Background Katsube et al. [1] used a PK/PD modeling and simulation approach to determine the most effective dosage regim...
Influenza pandemics and seasonal outbreaks have shown the potential of Influenza A virus (IAV) to enhance susceptibility to a secondary infection with the bacterial pathogenStreptococcus pneumoniae(Sp). The high morbidity and mortality rate revealed the poor efficacy of antiviral drugs and vaccines to ...
Pharmacokinetic/pharmacodynamic (PK/PD) studies of human regular U-500 insulin (U-500R) at high doses commonly used in clinical practice (>100 units) have not been performed. The current analysis applied PK/PD modeling/simulation to fit the data and simulate single-dose and steady-state PK/...
Comparing Model Performance in Characterizing the PK/PD of the Anti㎝yostatin Antibody DomagrozumabModeling and simulation provides quantitative information on target coverage for dose selection. Optimal model selection often relies on fit criteria and is not necessarily mechanistically driven. One such ...
The industry's most trusted PK/PD platform for non-compartmental analysis (NCA), population PK (popPK), IVIVC, and more. Find out more...
Modeling and Simulation in Drug Development with SimBiology(51:45)- Video SimBiology Tutorials for QSP, PBPK, and PK/PD Modeling and Analysis(10 videos)- Video Building a Model – Differential Equations | SimBiology Tutorials for QSP, PBPK, and PK/PD Modeling and Analysis(8:25)- Video ...
Pharmacokinetic (PK) and Pharmacodynamic (PD) Modeling and Simulation Support the Novelty of MN-221, a Highly Selective Beta2-Adrenergic Receptor Agonist for Treatment of Acute Asthma 来自 dx.doi.org 喜欢 0 阅读量: 6 作者:BM Sadler,AW Dunton,M Feldman,K Matsuda,J Bosley,R Beaver ...