comprising macrophages (Mφs) and dendritic cells (DCs), play important roles in the generation and the regulation of immune responses to intestinal antigens, and alterations in the development and/or the function of these cells are thought to contribute to the pathogenesis of inflammatory bowel ...
Methionine sulfoxide reductases: Selenoprotein forms and roles in antioxidant protein repair in mammals Msrs (methionine sulfoxide reductases), MsrA and MsrB, are repair enzymes that reduce methionine sulfoxide residues in oxidatively damaged proteins to meth... HY Kim,VN Gladyshev - 《Biochemical Journ...
NAMPT is able to modulate processes involved in the pathogenesis of obesity and related disorders by influencing the oxidative stress response, apoptosis, lipid and glucose metabolism, inflammation and insulin resistance Levels of extracellular NAMPT are associated with various metabolic disorders NAMPT, whi...
Biochemical investigation identifies many substrates of miR-155, and one of them in B cells and macrophages is the SH2-domain containing inositol-5′-phosphatase 1. A deficiency of miR-155 in the immune system causes attenuated immune functions. Clinically, several types of malignancy including ...
This response relies mainly on tissue-resident macrophages and is intermediate between the basal homeostatic state and a classic inflammatory response. Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases. This is a preview of ...
Curat, C. A.et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin.Diabetologia49, 744–747 (2006). ArticleCASPubMedGoogle Scholar Romacho, T., Sánchez-Ferrer, C. F. & Peiró, C. Visfatin/Nampt: an adipokine with cardi...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of research have been carried out to understand the role of AhR as a novel mechanism for disease de
Origin and physiological roles of inflammation 热度: The origin of life and evolution生命的起源与进化.ppt 热度: 论人类不平等的起源A Discourse Upon The Origin And The Foundation Of The Inequality Among Mankind - Jean, Jacques Rousseau 热度: ...
Activation of eosinophils, neutrophils, and macrophages elicits powerful respiratory burst associated with reduction of molecular oxygen to superoxide via activation of the NADPH oxidase complex, which consists of five proteins residing in resting cells in the cytosol or membrane of intracellular vesicles,...
Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation ArticleOpen access The Role of IL-6 in Neurodegenerative Disorders Article16 January 2024 References Achim C. L., Heyes M. P., and Wiley C. A. (1993) Quantitation of human immunodeficiency virus...