Gumz ML, Stow LR, Lynch IJ, Greenlee MM, Rudin A, Cain BD, Weaver DR, Wingo CS (2009) The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice. J Clin Invest 119:2423-2434.Gumz ML, Stow LR, Lynch IJ, et al. The circadian clock ...
Circadian oscillations of mRNAs and proteins are the main features of circadian clock genes. Among them, Period1 (Per1) is a key component in negative-feedback regulation, which shows a robust diurnal oscillation and the importance of circadian rhythm and translational regulation of circadian clock...
The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1 Weaver DR, Lee C (2011) The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1... ...
The circadian clock machinery controls various downstream events through transcription, translation, or degradation processes. The results of the present study demonstrated that the core circadian clock component PER2 caused the time-dependent expression ofSlc9a3r1/NHERF1 in the livers of mice through ...
1 –1 –2 –3 –4 0 E30 E34 –5 P1 Late change 0 –2 –4 –6 –8 E30 E34 P1 20 16 12 8 4 0 –4 Signal peptide 0 0.2 0.4 0.6 0.8 1.0 Cell adhesion Response to hormones Response to ions Response to steroids Circadian rhythm 012345 Differentiation Signal peptide Membrane Binding ...
The circadian clock is a major regulator of physiology and behavior through the temporal control of gene expression programs on a 24 h scale. The molecular role and mechanism of action of clock genes in developmental processes have lately received increased interest [[59], [60], [61], [62]...
Prenatal stress-related alterations to child HPA axis functioning additionally have been linked to circadian cortisol production. Prenatal maternal psychological distress is associated with a flattening of thecortisol awakening responseat 10 years of age (O'Connor et al., 2005) and with a flattened di...
A well characterized output of the circadian clock in plants is the daily rhythmic movement of leaves. This process has been used extensively in Arabidopsis to estimate circadian period in natural accessions as well as mutants with known defects in circa
Our data support the circadian gene mPer2 as a new intrinsic regulator of both the proliferation and differentiation in NPCs of the adult murine DG. Interestingly, mPER2 could belong to a global machinery that coordinates the proliferation with the differentiation of NPCs as other molecules (FGF-...
Here we show that the expression of Period 2 (Per2), a circadian regulator, is directly regulated by p53 binding to a response element in the Per2 promoter. This p53 response element is evolutionarily conserved and overlaps with the E-Box element critical for BMAL1/CLOCK binding and its ...