其中ESX-5型分泌系统主要参与结核分枝杆菌大部分PE、PPE家族蛋白分泌等。PE、PPE蛋白家族其蛋白N端富含谷氨酸、脯氨酸,根据PE、PPE蛋白家族不同结构,PE家族可分为PE和PE_PGRS两个亚类,PPE可分为PPE,PPE_MPTR,PPE_SVP和PPE_PPW四个亚类,目前大部分的PE、PPE蛋白功能还不明确。
The PE_PGRS protein family, characterized by a special N‐terminal PE (Pro (P)〨lu (E) motif) domain and a C‐terminal PGRS (Polymorphic GC‐rich Repetitive Sequences) domain, is restricted mainly to pathogenic mycobacteria. Here we summarize current literature on the PE_PGRS as vital ...
Fig1.检测PE_PGRS62抗体实验 同时,研究者还用PE_PGRS17做了同样的实验,发现三组实验对象中均检测不到PE_PGRS17抗体,说明不同PE_PGRS蛋白引起的细胞反应效果不同[1]。 另外,研究人员检测了结核菌诊断中常用的38KD抗体,发现该抗体含量变化趋势与PE_PGRS62抗体变化趋势相反,结核病治愈者的38KD抗体比未治愈患者的...
PE_PGRS represent a large family of proteins typical of pathogenic mycobacteria whose members are characterized by an N-terminal PE domain followed by a large Gly-Ala repeat-rich C-terminal domain. Despite the abundance of PE_PGRS-coding genes in theMycobacterium tuberculosis(Mtb) genome their rol...
tuberculosis, as well as the generally lower numbers of PE/PE_PGRS genes in non-pathogenic mycobacteria, suggest that members of the PE/PE_PGRS gene family may have an important, although not yet identified, role in the success of M. tuberculosis as a human pathogen. It has been proposed ...
There is evidence that some members of the Mycobacterium tuberculosis PE_PGRS gene subfamily, including PE_PGRS33, may have a specific function in M. tuberculosis persistence. The impact of naturally-occurring PE_PGRS33 genetic variations on the virulence and transmissibility of clinical M. tuberculos...
Mutations in ppe38 block PE˙PGRS secretion and increase virulence of Mycobacterium tuberculosis. Nat Microbiol 2018;3:181-8.Ates, L. S. et al. Mutations in ppe38 block PE_PGRS secretion and 533 increase virulence of Mycobacterium tuberculosis. Nat. Microbiol. 3, 534 181-188 (2018)....
A. (2016) Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47. Nature microbiology 1, 16133Saini NK, Baena A, Ng TW, et al. Suppression of autophagy and antigen presentation by Mycobac- terium tuberculosis PE_PGRS47. Nat Micro- biol [Internet]. 2016;1(9...
The highly homologous PE_PGRS (Proline-glutamic acid_polymorphic GC-rich repetitive sequence) genes are members of the PE multigene family which is found only in mycobacteria. PE genes are particularly abundant within the genomes of pathogenic mycobacter
热度: 女孩要富养--杨澜269 热度: 相关推荐 280502C社会科学总论13371579-Mycobacterial PE_PGRS Proteins Contain Calcium-Binding Motifs with Parallel β-roll Folds,280502C社会科学总论13371579-Mycobacterial PE_PGRS Proteins Contain Calcium-Binding Motifs with Parallel β-roll Folds,PE,帮助博学...