研究背景:PD-L1 蛋白在诱导和维持自身免疫耐受方面发挥着关键作用,作为抑制性受体 PDCD1/PD-1 的配体,从而调节 T 细胞的激活阈值,最终限制其效应反应。此外,PD-L1 可能作为 T 细胞亚群的共刺激分子,主要通过尚未鉴定的激活受体产生白细胞介素 10 (IL10)。除了作为免疫检查点的作用外,PD-L1 还充当转录共激活因...
Different Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages. PMID: 34675601 Effects of Tussilago farfara L. Polysaccharides on the Expression of PD-1 (CD279) and PD-L1 (CD274) in Peripheral Blood and Tumor Tissue Lymphocytes in Mic...
一、PD-L1蛋白抗体药物也入脑 对于PD-L1抑制剂阿替利珠单抗我们并不陌生,这是一款在我国也上市的免疫治疗药物,获批用于小细胞肺癌、肺癌等多个类型的恶性肿瘤。下面这项研究属于单臂二期临床试验,招募的晚期非鳞状非小细胞肺癌,这些患...
Different Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages. PMID: 34675601 Effects of Tussilago farfara L. Polysaccharides on the Expression of PD-1 (CD279) and PD-L1 (CD274) in Peripheral Blood and Tumor Tissue Lymphocytes in Mic...
KRAS和TP53基因在PD-L1表达较高,吸烟和细胞周期失调相关,存在这两个基因突变的患者有较高数量的体细胞基因突变,有研究报道KRAS基因突变的肺癌患者往往可以从PD-1受益。当然现在KRAS基因的G12C突变有了靶向药,但是其他的突变位点暂时没...
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy. PMID: 34539412 Revisiting the PD-1 pathway. PMID: 32948597 PD1 Blockade in Cancer: Impact on Myeloid Cells. PMID: 32459997 Understanding the role of PD-L1/PD1 pathway blockade and autophagy in cancer therapy. PMID: 28367063 ...
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy. PMID: 34539412 Revisiting the PD-1 pathway. PMID: 32948597 PD1 Blockade in Cancer: Impact on Myeloid Cells. PMID: 32459997 Understanding the role of PD-L1/PD1 pathway blockade and autophagy in cancer therapy. PMID: 28367063 ...