Given that abnormal alpha-synuclein (α-syn) accumulation is a primary component of PD pathology, this protein has attracted considerable interest as a potential biomarker for PD. Alpha-synuclein can be detected in several body fluids, including plasma, where it can be found as free form or in...
1、以α-syn为靶点的在研药物16 2、LRRK2激酶抑制剂BIIB12219 3、GLP-1受体激动剂20 4、其他靶点在研药物21 (四)国内多款在研PD药物处于1期/2期临床阶段23 三、PD药物市场规模将持续扩大24 (一)中国PD患者预计2030年将达500万人,占全球PD患者人数的一半24 (二)全球PD药物市场预计2029年将达66.3亿美元25...
Alpha-synuclein (α-syn) pathology is the hallmark of Parkinsons disease (PD). The leucine-rich repeat kinase 2 ( LRRK2 ) gene is a major-effect risk gene for sporadic PD (sPD). However, what environmental factors may trigger the formation of α-syn pathology in carriers of LRRK2 risk...
coli can specifically colonize into the hypoxic region of GBM and activate the innate immune response, causing a short-term increase in innate inflammatory molecules such as tumor necrosis factor-alpha (TNF-α), interferon gamma (IFN-γ), interleukin-6 (IL-6), interleukin-1beta (IL-1β), ...
转录因子FOXO3a在PD中的作用及机制研究 秦晋中;肇玉明 【期刊名称】《脑与神经疾病杂志》 【年(卷),期】2024(32)1 【摘要】帕金森病(Parkinson’s disease,PD)是以黑质致密部(substantia nigra pars compacta,SNpc)多巴胺能神经元的丢失和α-突触核蛋白(alpha-synuclein,α-Syn)的异常聚集为主要特征的神经退行...
图一:B6-hSNCA A53T小鼠α-Syn聚集检测 8周龄B6-hSNCA A53T小鼠中脑及脑桥区域开始出现α-Syn蛋白胞质内聚集。 图二:B6-hSNCA A53T小鼠疲劳旋转棒测试 12周龄B6-hSNCA A53T小鼠在棒运动时间与B6小鼠无差异。 B6-Tfam-flox/Slc6a3-Cre模型数据...
目的:(1)探究G2019S LRRK2在A53Tα-Syn转基因小鼠体内如何干预α-Syn病理学改变,G2019S LRRK2和A53Tα-Syn基因突变对PD小鼠的症状影响。(2)白藜芦醇对A53T/G2019S双转基因小鼠的保护机制。方法:(1)分别使用旷场实验、转棒实验、爬杆实验检测WT、A53T HET、G2019S HOMO、G2019S HET、A53T/G2019S 5...
(cannabidivarin,CBDV)对线虫体内α-syn聚集的抑制作用及其机制,为研究CBDV治疗PD奠定理论基础,为CBDV进一步转化成PD临床药物提供理论依据.1.次大麻二酚对转基因线虫PD模型表型的影响用不同浓度梯度的CBDV处理转基因线虫PD模型NL5901[unc-54p::alpha synuclein::YFP+unc-119(+)]进行寿命实验,结果显示,50μmol/L...
别名:G2-3(A53T), PrPsynA53T, A53TαS Tg mice (line G2-3), MoPrP-Huα-Syn(A53T), Hualpha-Syn(A53T), A53T aSyn Tg Mouse (Lee), alpha-synuclein A53T Mouse (Tg) 物种:小鼠 基因:SNCA 突变:SNCA*A53T 编辑类型:SNCA - 转基因 ...
近日,苏州大学附属第二医院、苏州大学神经科学研究所刘春风教授团队在npj Parkinson’s Disease杂志上发表了题为“Circadian disruption promotes the neurotoxicity of oligomeric alpha-synuclein in mice”的研究论文。博士研究生张金宝为本文第一作者。该研究证实病理性α-突触核蛋白(αSyn)寡聚体可以通过鼻-脑传递通路...