LncRNA PAXIP1-AS1肺动脉高压ETS1WIPF1RhoA研究背景:肺动脉高压(Pulmonary arterial hypertension,PAH)是由多种异源性疾病和不同发病机制所致肺动脉血压力异常增高的一种疾病,可引起肺血管阻力和肺动脉压力升高的临床和病理生理综合征,主要特征是以肺血管阻力进行性升高和右心功能进行性衰竭.随着肺动脉压力升高,患者...
学术交流 中心简介 通知公告 人才队伍 文件下载 联系我们 科研设备【学术交流讲座】长非编码RNA PAXIP1-AS1通过招募转录因子ETS1上调KIF14的表达,促进胶质瘤的细胞侵袭和血管生成发布时间:2022/3/28 8:46:16 浏览次数:1435次https://pubmed.ncbi.nlm.nih.gov/31823805/ 上一篇:【学术交流讲座】肿瘤免疫治疗用...
Retraction Note: H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axisYimin Ma & Wei Zheng Journal of Ovarian Research volume 16, Article number: 239 (2023) Cite this article ...
HOXD9过表达细胞的RNA测序和HGNC数据库分析确定并注释了14个差异表达的lncRNA(图1B),TCGA数据库发现低表达PAXIP1-AS1的GC患者的总生存期较短,因此选择PAXIP1-AS1做进一步研究。HOXD9的过表达(图1C1)或敲低(图1C2)证实了HOXD9与PAXIP1-AS1的表达呈负相关。 接着,软件预测发现HOXD9在PAXIP1-AS1启动子区...
PAXIP1-AS1 was significantly downregulated in OC cell lines compared with IOSE29 cell line. The expression of PAXIP1-AS1 was associated with immune infiltration. low expression of PAXIP1-AS1 was correlated with poor OS (HR: 0.52; 95% CI: 0.34-0.80; P = 0.003) from GSE138866. There ...
PAK1CYTOSKELETONMETASTASISLong non-coding RNAs (lncRNAs) have been functionally characterised in various diseases. LncRNA PAX-interacting protein 1-antisense RNA 1 (PAXIP1-AS1) has reportedly been associated with cancer development. However, its role in gastric cancer (GC) remains poorly understood....