长链非编码RNA(Long non-coding RNAs,LncRNAs)与多种类型癌症的致癌过程密不可分.PAX8在非小细胞肺癌中过表达,并推测PAX8很可能干扰P53转录而促进肿瘤的发展.进一步研究还发现PAX8基因的沉默可以降低非小细胞肺癌的活性和迁移.本研究首次探索lncRNA PAX8-AS1的rs4848320和rs1110839多态性与肺癌易感性的关系.方法:1....
Additionally, rescue assays in osteoblasts clarified the regulatory network of the PAX8-AS1/miR-1252-5p/GNB1 axis. Finally, in vivo loss-of-function studies verified the role of PAX8-AS1 in OP progression. The results illustrated that PAX8-AS1 was upregulated in the proximal tibia of OP rats...
长链非编码RNA(Long non-coding RNAs,LncRNAs)与多种类型癌症的致癌过程密不可分.PAX8在非小细胞肺癌中过表达,并推测PAX8很可能干扰P53转录而促进肿瘤的发展.进一步研究还发现PAX8基因的沉默可以降低非小细胞肺癌的活性和迁移.本研究首次探索lncRNA PAX8-AS1的rs4848320和rs1110839多态性与肺癌易感性的关系.方法:1....
Among the stage II patients with high PAX8-AS1 level, administration of fluorouracil-based adjuvant chemotherapy provided a substantial improvement in RFS (P = 0.002, Figure 3C). Further mechanistic study unveiled that PAX8-AS1 increases the response of CRC cells to chemotherapy in vitro and in ...
目的观察lncRNA PAX8-AS1对小鼠急性心肌梗死(AMI)后心肌细胞凋亡的调控影响.方法通过左冠状动脉前降支结扎构建AMI模型小鼠.取AMI模型构建成功的雄性小鼠64只,随机选择48只小鼠,于术后0,1,2,3,4,5 d各处死8只小鼠,作为AMI组.小鼠选择方式同AMI组,并采取与AMI小鼠相同的手术方式,但不进行左冠状动脉前降支结扎,...
腹腔热灌注化疗lncRNAPAX8-AS1RBM4热化疗敏感性卵巢癌作为最常见的妇科恶性肿瘤之一,严重威胁了妇女健康.目前多种联合治疗方法的临床应用,如联合腹腔热灌注化疗(HIPEC),很大程度上提高了晚期卵巢癌患者术后的生存期.但是,部分卵巢癌对热疗存在一定的耐热性,影响了腹腔热灌注化疗的治疗效果.目前研究证明,长链非编码RNA(...
Retracted: LncRNA-PAX8-AS1 Silencing Decreases Cell Viability, Enhances Apoptosis, and Suppresses Doxorubicin Resistance in Myeloid Leukemia via the miR-378g/ERBB2 Axis[This retracts the article DOI: 10.1155/2022/2295044.].doi:10.1155/2023/9829428...
Expression quantitative trait loci in long non-coding RNA PAX8-AS1 are associated with decreased risk of cervical cancer. Mol Genet Genom (MGG). 2016;291(4):1743-8.Han J, Zhou W, Jia M, et al. Expression quantitative trait loci in long non-coding RNA PAX8-AS1 are associated with ...
Long non-coding RNA PAX8-AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia. 来自 ResearchGate 喜欢 0 阅读量: 46 作者:B Gholamreza,H Mohammad,N Majid,S Simin,T Mohsen 摘要: Background: The present study was aimed to examine the possible association between methylene ...
This study demonstrates that PAX8/PAX8-AS1 DNA methylation levels are associated with total sleep time in persons with unexplained hypersomnolence. Given prior investigations that have implicated single nucleotide polymorphisms in PAX8/PAX8-AS1 with habitual sleep duration, further research that clarifies...