Breast cancer patients (∼40%) experience debilitating cancer-related fatigue (CRF), and efficacious treatment options are limited due in part to lack of understanding of the underlying pathophysiology. One promising avenue for treatment discovery is investigation of inflammation effects on CNS pathways...
Effects of Estrogen on Apoptotic Pathways in Human Breast Cancer Cell Line MCF-7 We utilized a reverse transcription-PCR method to examine the effect of estrogen on the expression of mRNA for Bcl-2 and Bax, two modulatory proteins in th... TTY Wang,JM Phang - 《Cancer Research》 被引量:...
Dysregulated expression of dicer and drosha in breast cancer. Pathol. Oncol. Res. 18, 343–348 (2012). Article CAS PubMed Google Scholar Sand, M. et al. Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components ...
In sporadic breast tumorigenesis, at least three different pathway-specific mechanisms of tumour progression are recognizable, with breast carcinogenesis being different in ductal versus lobular carcinoma, and in well differentiated versus poorly differentiated ductal cancers. Thus, different breast cancer ...
The objective of this study was to determine if information obtained from a limited sample (i.e., a single gel replicate) can provide insight into the predominant pathways in two well-characterized breast cancer models. Methods A comparative proteomic analysis of total cell lysates was obtained ...
Both TGF-β and the PI3K-AKT signaling pathways are known activators of various intracellular pathways that regulate critical cellular functions, including cancer cell survival and proliferation. The interplay between these two oncogenic pathways plays a
Hence, targeting these pathways might be a novel therapeutic approach for breast cancer diagnosis and therapy. This review discusses known signaling mechanisms involved in the stimulation or prevention of BCSCs self-renewal, metastasis, and tumorigenesis. 展开 关键词: Breast cancer Breast cancer stem ...
Breast cancer biomarkersSeventy gene signatureErbB2 overexpressionFibroblast core serum responseWe explain the recent increases h l obesity in the United States... MARY A. BURKE,FRANK HEILAND - 《Economic Inquiry》 被引量: 341发表: 2007年
www.nature.com/scientificreports OPEN An in‑silico method leads to recognition of hub genes and crucial pathways in survival of patients with breast cancer Sepideh Dashti1, Mohammad Taheri2 & Soudeh Ghafouri‑Fard1* Breast cancer is a highly heterogeneous disorder ...
while TRMs tend to shape the extracellular matrix.46In lung cancer, TAMs primarily facilitate tumor metastasis, whereas TRMs mainly support tumor growth.58TRMs manifest a more pronounced M2 phenotype in breast cancer than MDMs.38In brain tumors, microglia show a stronger inclination towards pro-infla...