首先是帕金森的"病生理学"Pathophysiology: Parkinson’s disease is caused by the deposition of Lewy body in substantia nigra (part of basal ganglia) leads to the death of dopaminergic neurons and subsequent symptoms from dopamine deficiency. 1.Lewy body意为"路...
Parkinson's disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease, as it brings an additional significant...
has developed artificial intelligence-enabled digital pathology technologyto detect Parkinson’s disease (PD), and new research conducted in collaboration with the Michael J. Fox Foundation (MJFF) shows it accurately detects the disease before the onset of severe symptoms....
Background: Even with numerous studies the cause of Parkinsons disease (PD) remains elusive. It has been hypothesized that interactions between genetic and environmental factors may play an important role in the pathogenesis of PD. Objectives: To examine the gene-gene and gene-environment interaction...
Abnormal accumulation of α-synuclein and mitochondria dynamics dysfunction are considered to be implicated in the pathogenesis of Parkinson's disease. However, the underlying mechanisms how α-synuclein abnormal accumulation causes mitochondrial dynamics dysfunction remains unclear. Here, we demonstrate that ...
She told him, “It doesn’t feel like I have Parkinson’s disease.’” The other thing that made Alberts take notice was when Cathy mentioned her handwriting had improved. Patients with Parkinson’s often develop micrographia, where their handwriting becomes small and illegible. ...