Since the FDA has recommended the dose of 4000 mg (in any 24 h period) as a maximum dose of APAP for treatment [19], it can be indicated that the dose of APAP used in the present study was within the therapeutic dose range [5,7]. 2.3. Experimental Design The experiment in this ...
In a systematic review of recommendations and guidelines for managing OA pain, the Chronic Osteoarthritis Management Initiative of the U.S. Bone and Joint Initiative, paracetamol was the first-line treatment across guidelines [90]. Although it reports findings questioning its efficacy, the NICE ...