In wild-type p53-expressing cancer cells, p53 in one hand transactivates BAX and in parallel up-regulates p53-induced death domain protein (PIDD) that in turn cleaves and activates BID through caspase-2. Both BA
Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat. Genet. 26, 122–127 (2000). Article CAS PubMed Google Scholar Lehar, S. M. et al. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene 12, 1181–...
Bcl-2 associated X-protein Bcl-2 B-cell lymphoma 2 CAD caspase 3 activated DNase DISC death-inducing signaling complex FADD Fas associating protein with death domain Mcl-1 induced myeloid leukemia cell differentiation protein NuMA nuclear mitotic apparatus protein p53 tumor protein 53 PARP poly(...
AE-expressing cells have an activated p53 pathway and increased sensitivity to induced DNA damage We have examined the consequences of increased DNA damage in AE cells. At 5 weeks after transduction, AE cultures showed increased protein levels of p53 and its target p21, as well as increased tran...
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and ...
Protein A/G 保存液 PBS, pH 7.4, with 0.2% BSA 内含物 0.09% sodium azide 保存条件 4°C, store in dark 运输条件 Ambient (domestic); Wet ice (international) RRID AB_2896864 产品详细信息 Recombinant rabbit monoclonal antibodies are produced using in vit...
Immunogen Recombinant protein Gene ID 7157(Human) SwissProt P04637(Human) Synonyms BCC7; LFS1; P53; TRP53 Category Cell Cycle Background p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related...
ImmunogenRecombinant protein Gene ID7157(Human) SwissProtP04637(Human) SynonymsBCC7; LFS1; P53; TRP53 CategoryCell Cycle Backgroundp53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in respons...
Before induction the cells were trans- ferred into a minimal broth containing 50 mM Na2HPO4, 20 mM 18.7 KmHM2PNOH44,C8l.5anmdM22N.2amClM, 1gmluMcosCea(Cinl21,52Nm/13MC-MlabgeSlOle4d, form). The expression was induced with 0.25 mM isopropyl β-d-1-thio...
Toronto, ON, Canada The Pidd (p53-induced protein with death domain) gene was shown to be induced by the tumour suppressor p53 and to mediate p53-dependent apoptosis in mouse and human cells, through interactions with components of both the mitochondrial and the death receptor signalling pathways...