The aim of this study was to evaluate the association of HPV and HIV status, p16 expression level and TP53 mutations with the absence of residual tumors (local response) in Squamous Cell Carcinoma (SCC) of the anal canal after chemoradiotherapy. Methods We performed a study on 78 patients ...
The aim of this study was to evaluate the association of HPV and HIV status, p16 expression level and TP53 mutations with the absence of residual tumors (local response) in Squamous Cell Carcinoma (SCC) of the anal canal after chemoradiotherapy. Methods: We performed a study on 78 patients ...
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Feline papillomavirus L1 (major capsid) DNA was not detected in the SCC cell lines or the FOSCCs with high p16 immunostaining. Five of 6 (83%) of the high p16 FOSCC had low p53, but only 1/6 (17%) had low pRb immunoreactivity. In summary, the staining pattern of p16, p53, and...
(a–c) Haematoxylin and eosin stained sections from three anal SCCs. (d) Corresponding adjacent section showing p16INK4A positive invasive tumour cells. (e) SCC infiltrating the underlying stroma exhibiting diffuse strong nuclear positivity for p53. (f) Diffuse predominantly membranous positivity for...
We identified advanced stage, non-SCC cervical cancer, and low P16INK4A expression were independent poor factors of DFS. In the cell line data, low P16INK4A expression was associated with a higher expression of stem cell markers and the ability of cells to self-renew. Our data not only ...