结果:与正常皮肤组织相比,NF-κB/P65,p-ⅠκBα和ⅠκKα三者在SCC,BCC中均高表达(P〈0.05);三者在SCC和BCC中的表达具有统计学意义(P〈0.05):IκK蛋白的表达与SCC的分化程度无明显相关性(P〉0.05).在BCC和SCC中,ⅠκKα的表达与p-ⅠκBα表达呈正相关关系(r=0.536,P〈0.05),NF—κB/P65和p—Ⅰ...
4.4Downregulation of NF-κβ pathway activation Nuclear factor-kappa B is a protein involved in various responses like cell survival, cell cycle, apoptotic pathways, and inflammation. It regulates the transcription of genes such as cytokines like IL-1, IL-8, pro-inflammatory mediators, chemokines,...
显。NF-κB能够与ABCB1基因启动子区域结合。结论：阻断PI3K/AKT信号通路可增强人结肠癌HCT-116/L-OHP 耐药细胞的药物敏感性，抑制p-Akt和p-IκB的磷酸化表达水平，逆转P-gp介导的肠癌多药耐药。 ［关键词］ 结肠癌；多药耐药；P-糖蛋白；磷脂酰肌醇-3-激酶；核转录因子κB DOI: 10.3969/j.issn....
3039S Phospho-NF-kappa-B p65 (Ser468) Antibody Polyclonal Antibody 100 ul CNY 3,487 3031S Phospho-NF-kappa-B p65 (Ser536) Antibody Polyclonal Antibody 100 ul CNY 3,487 3031L Phospho-NF-kappa-B p65 (Ser536) Antibody Polyclonal Antibody 300 ul CNY 8,360 4810S Phospho-NF-kappa-B2 ...
Thermo-life PA174407 PIERCE GOAT ANTI-HUMAN IG, KAPPA LC (HRP) SECONDARY ￥5,326.00 KAPPA LC (HRP) SECONDARY Thermo-life PA184631 MONKEY IGG, H&L CHAINS (HRP) EA ￥5,326.00 EA Thermo-life 88828 PIERCE DIRECT MAGNETIC IP/CO-IP KIT ￥5,329.00 IP/CO-IP KIT Thermo-life 20349 STREPTAVID...
3039S Phospho-NF-kappa-B p65 (Ser468) Antibody Polyclonal Antibody 100 ul CNY 3,487 3031S Phospho-NF-kappa-B p65 (Ser536) Antibody Polyclonal Antibody 100 ul CNY 3,487 3031L Phospho-NF-kappa-B p65 (Ser536) Antibody Polyclonal Antibody 300 ul CNY 8,360 4810S Phospho-NF-kappa-B2 ...
(1) RelA/p65, a subunit of NFκB. (2) Proline-rich P65 protein of Mycoplasma pneumoniae (423aa). (3) Serine/threonine-protein kinase WNK1. (4) Synaptotagmin-1. (5) Golgi reassembly-stacking protein of 65 kDa (GRASP-65, 440aa). (6) In mouse, complement regulatory protein Crry (...
Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-kappa B/Rel family. J. Biol. Chem. 270, 23077–23083 (1995). Article CAS PubMed Google Scholar Friedmann-Morvinski, D. et al. Targeting NF-κB in glioblastoma: a therapeutic approach. Sci...
NF.KB;P糖蛋白类; 药物耐受性; 免疫组织化 学;疾病模型,动物 DOI:10.39690.issn.1672—6731.2011.02.022 EffectsofcelecoxibonexpressionofNF·-KBp65andP--gPinhippocampusofchronictemporallobe epilepticrats ZHANGXiuna,WUShijing,TAOHuaying,ZHANGLina.DepartmentofNeurology,Tianjin ...
Furthermore, we found that CuE also inhibited TNF-alpha-induced phosphorylation of NF-kappa Bp65, IKK alpha/beta, and I kappa B alpha in a dose-and time-dependent manner as well as NF-kappa Bp65 nuclear translocation. Finally, we showed that CuE blocked the upstream targets of NF-kappa ...