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Bosentan: May decrease the serum concentration of Progestins (Contraceptive). Management: Use an alternative (i.e., non-hormonal) means of contraception for all women of childbearing potential who are using bosentan, and do not rely on hormonal contraceptives alone.Consider therapy modification Briga...
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However, the pre-implantation diagnosis has some limitations: (I) it will only benefit women who have low levels of mtDNA mutations in oocytes [340] and, (II) it assumes that the diagnosed heteroplasmy level is representative of that of the entire embryo and would not change over time. 4.1...
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