12. R. Franket al., Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non-Small Cell Lung Carcinoma (NSCLC).Clin Cancer Res24, 3087-3096 (2018). 13. F. Goemanet al., Mutations in the KEAP1-NFE...
6.5分纯生信，Nrf2信号通路泛癌分析，是基因集泛癌就不会太差 公众号：生信小课堂 大家好，今天要和大家分享的是2022年2月发表的一篇文章：“Machine Learning Identifies Pan-Cancer Landscape of Nrf2 Oxidative Stress Response Pathway-Related Genes”。在这项研究中，作者对Nrf2信号通路相关基因进行了系统泛癌...
大家好,今天要和大家分享的是2022年2月发表的一篇文章:“Machine Learning Identifies Pan-Cancer Landscape of Nrf2 Oxidative Stress Response Pathway-Related Genes”。在这项研究中,作者对Nrf2信号通路相关基因进行了系统泛癌分析,包括Nrf2信号通路相关基因表达与肿瘤突变负荷(TMB)、微卫星不稳定性(MSI)、免疫表型、...
et al. NRF2 and the Hallmarks of Cancer. Cancer Cell. 2018; 34(1): 21-43.3. Qin JJ, et al. Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review. Cell Commun Signal. 2019; 17(1):...
we induced NRF2 via pharmacological inactivation of KEAP1 in a panel of 50+ non-small cell lung cancer cell lines. Unexpectedly, marked decreases in viability were observed in >13% of the cell lines—an effect that wasrescued by NRF2 ablation. Genome-wide and targeted CRISPR screens revealed ...
2019年6月27日，来自纽约大学医学院的ThalesPapagiannakopoulos和 MichelePagano团队在Cell杂志上发表了题为：Nrf2ActivationPromotesLungCancerMetastasisbyInhibitingtheDegradationofBach1的文章。他们的研究结果表明Nrf2能够通过抑制Bach1的降解导致肺癌的转移。 在所有的癌症中，肺癌是发病率和死亡率最高恶性肿瘤【1】。因此...
Nrf2 Keap1 Cancer Antioxidant response element Gene therapy Introduction The Keap1-Nrf2 pathway is the major regulator of cytoprotective responses to endogenous and exogenous stresses caused by reactive oxygen species (ROS) and electrophiles [1]. The key signaling proteins within the pathway are the ...
Natural products Cancer prevention Nrf2–ARE pathway Tumorigenesis Dietary phytochemicals 1. Introduction Tumorigenesis is a multiple-stage and multiple-factor process, typically divided into three stages, including initiation, promotion and progression [1]. Despite extensive global research aimed at ameliorat...
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The interplay between metabolism and chromatin signaling is implicated in cancer progression. However, whether and how metabolic reprogramming in tumors generates chromatin vulnerabilities remain unclear. Lung adenocarcinoma (LUAD) tumors frequently harbor aberrant activation of theNRF2antioxidant pathway, which...