However, p-ERK tended to decrease after 30 mins, indicating a transient activation of this signaling. As evidenced by qPCR assays, PD and Tetrac attenuate the increase on alpha-actin and ANF mRNA levels promoted by T3. Similar results were also observed for [ 3 H]-leucine incorporation (...
Therefore, cervico-vaginal secretion cytokine profiling might be a new, non-invasive approach to study the endometrial receptivity in IVF management.doi:10.1111/aji.13064Zanotta, NunziaMonasta, LorenzoSkerk, KristinaLuppi, StefaniaMartinelli, Monica...
Kagechika, L.-N. Wei, All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation, Sci. Rep. 6 (2016)Persaud S.D, Persaud SD, Park SW, Ishigami-Yuasa M, Koyano-Nakagawa N, Kagechika H, et al. (2016) All trans-retinoic...
Cav1 downregulation changes the kinetic of p-ERK1/2 activation in non-proliferating mesPC and A1 cells.Floriana VolpicelliMassimiliano CaiazzoBruno MoncharmontUmberto di PorzioLuca ColucciD’Amato
They have implications on the evolution of the ERK signalling pathway and suggest a mechanism for its co-option in the course of evolution.ERK signalling is a core developmental pathway that is canonically activated by RTKs through activated RAS. Here they show that the process of ERK activation...
The ERK-independent PS cells described herein will provide a useful resource for testing interspecies organogenesis strategies. ? 2019 by John Wiley & Sons, Inc.The production of human organs inside human-animal interspecies chimeras might one day comprise a viable strategy for generating patient-...
Zhang YN,Wu XY,Zhong N,et al.Stimulatory effects of sorafenib on human nonsmall cell lung cancer cells in vitro by regulating MAPK/ERK activation[J].Mol Med Rep,2014,9(1):365-9.Stimulatory effects of sorafenib on human non?small cell lung cancercells in vitro by regulating MAPK/ERK ...
The Kaposi's sarcoma associated herpesvirus protein ORF45 binds the extracellular signal-regulated kinase (ERK) and the p90 Ribosomal S6 kinase (RSK). ORF45 was shown to be a kinase activator in cells but a kinase inhibitor in vitro, and its effects on the ERK-RSK complex are unknown. ...
Wei F, Yan J, Tang D, Lin X, He L, Xie Y, et al. Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation. Biochim Biophys Acta. 2013;1833(1):90-100....
Although previous studies indicate that PRL-1 promotes cell growth and migration by activating both the ERK1/2 and RhoA pathways, the mechanism by which it activates these signaling events remains unclear. We have identified a PRL-1-binding peptide (Peptide 1) that shares high sequence identity ...