ER stress is a hallmark of flavivirus infections, cancer development, chemotherapy-induced immunogenic cell death, radiotherapy and senescence.7,8 The authors show that ER stress–induced ecto-CRT serves as a danger-associated molecular pattern, helping NK cells identify and eliminate infected, maligna...
1.https://onlinelibrary.wiley.com/doi/10.1002/eji.202049028 2.https://www.researchgate.net/publication/236070665_Natural_Cytotoxicity_Receptors_Broader_Expression_Patterns_and_Functions_in_Innate_and_Adaptive_Immune_Cells 3.https://onlinelibrary.wiley.co...
ER stress is a hallmark of flavivirus infections, cancer development, chemotherapy-induced immunogenic cell death, radiotherapy and senescence.7,8 The authors show that ER stress–induced ecto-CRT serves as a danger-associated molecular pattern, helping NK cells identify and eliminate infected, maligna...
Remarkably, our immune system has developed a unique cell type called Natural Killer (NK) cells, able to kill cancer and virus-infected cells. The nature of the lysis/killer receptors expressed on NK cells, mediating this killing, and their ligands, is only little understood. Four lysis ...
2023年4月5日,哈佛医学院 Caroline Junqueira和 Judy Lieberman团队在Nature上发表了一篇主题为“The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells”的研究论文,其研究发现了NKp46识别外在化内质网钙结合蛋白(exo-CRT)...
2.https://www.researchgate.net/publication/236070665_Natural_Cytotoxicity_Receptors_Broader_Expression_Patterns_and_Functions_in_Innate_and_Adaptive_Immune_Cells 3.https://onlinelibrary.wiley.com/doi/10.1002/eji.202048953 4.DOI:10.1038/35059110
cancer development, chemotherapy-induced immunogenic cell death, radiotherapy and senescence.7,8 The authors show that ER stress–induced ecto-CRT serves as a danger-associated molecular pattern, helping NK cells identify and eliminate infected, malignant, stressed or senescent cells. IFN, interferon.[...
NK cellsNKp46Ncr1Natural killer (NK) cells are cytotoxic cells that are able to rapidly kill viruses, tumor cells, parasites, bacteria, and even cells considered self. The activity of NK cells is controlled by a fine balance of inhibitory and activating signals mediated by a complex set of ...
3.https://www.researchgate.net/publication/236070665_Natural_Cytotoxicity_Receptors_Broader_Expression_Patterns_and_Functions_in_Innate_and_Adaptive_Immune_Cells 4.https://onlinelibrary.wiley.com/doi/10.1002/eji.202048953 5.DOI:10.1038/35059110
2.https://www.researchgate.net/publication/236070665_Natural_Cytotoxicity_Receptors_Broader_Expression_Patterns_and_Functions_in_Innate_and_Adaptive_Immune_Cells 3.https://onlinelibrary.wiley.com/doi/10.1002/eji.202048953 4.DOI:10.1038/35059110