NF-kappa BTumor Necrosis Factor自身分泌性细胞交流肺肥大细胞NF-κB肿瘤坏死因子The generation of cytokines, particularly TNF-alpha, by mast cells is crucial for the initiation of the allergic response. A key transcription factor involved in the synthesis of TNF-alpha is NF-kappaB. Using a mAb ...
The Effects of NF-kappa B Signalling on the TNF-alpha-induced Ratios of MMPs to TIMPs in Chondrocytes 中文关键词:软骨细胞 肿瘤坏死因子-α 核因子-κB 基质金属蛋白酶家族 基质金属蛋白酶组织抑制剂家族 英文关键词:Chondrocyte TNF-α NF-κB MMPs TIMPs ...
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that has an important role in immunity and inflammation by inducing cellular responses such as apoptosis. The transcription factor nuclear factor-kappaB (NF-kappaB) can paradoxically suppress and promote apoptosis in response to TNF-alpha. In th...
Tumor necrosis factor (TNF ) is a potent pro-inflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation and apoptosis. This paper presents a simulation study of the TNF mediated NF- B signaling pathway based on a system-...
Telmisartan Inhibits TNF alpha-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells adhesion to astrocytes, and that this response was mediated by the inhibition of JNK/ERK1/2/NF-kappa B activation and in the PPAR-independent manner. ... C ...
目的:通过观察肿瘤坏死因子(TNF-α)以及核转录因子κB(NF-κB)在颅脑损伤后脑组织中的表达变化,初步探讨两者在颅脑损伤后继发性脑损伤中的意义。方法:健康成年雄性SD大鼠64只,体重230-310g,随机分成对照组8只和颅脑损伤组56只,颅脑损伤组在外伤后1h、3h、6h、12h、24h、3d、
Exposure to TNF-α resulted in an increase in the production of reactive oxygen species, number of apoptotic cells, caspase-3 activation and PARP cleavage. Increased oxidative stress by using H2O2 also caused apoptosis. These changes due to TNF-α were associated with an increase in IKK and NF...
Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling. Cytokine 2015; 75: 117-126.Bauer D, Redmon N, Mazzio E, Taka E, Reuben JS, et al. (2015) Diallyl disulfide inhibits TNFalpha induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling...
Activation of cytokine expression occurs through the TNF alpha /NF- kappa B-mediated pathway in birnavirus-infected cellsActivation of cytokine expression occurs through the TNF alpha /NF- kappa B-mediated pathway in birnavirus-infected cellsWangW...
alpha(1) adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-alpha production via modulating ERK1/2 and NF-kappa B pathway Furthermore, phenylephrine (PE), an (1)-AR agonist, also suppressed LPS-induced TNF- production. NE inhibited p38 phosphorylation and NF-B activati...