B signaling pathway s play all important role.G eneti c, metabolic or mechanical factors cause an in itial injury to th e cartilage resulting in release of several cartilage spe cifi c auto—an tigens,which trig ger th e activ ation of imune response.Imune cells inc luding T cells,B ...
NF-kappa B also plays an important role in a novel, radiation-inducible signaling pathway that involves the ataxia-telangiectasia mutated (ATM) protein kinase. Cells from patients with ataxia-telangiectasia (AT) are exquisitely sensitive to ionizing radiation and exhibit impaired NF-kappa B activation...
NF-B controls a number of genes involved in immuno-inflamma... T Okamoto,T Sanda,K Asamitsu - 《Current Pharmaceutical Design》 被引量: 242发表: 2007年 IκBKβ and NFκB1, NSAID use and risk of colorectal cancer in the Colon Cancer Family Registry The NFκB-signaling pathway regulates...
acute exacerbation of chronic obstructive pulmonary diseaseReduning injectionToll-like receptor 4/nuclear factor-kappa B inflammatory signaling pathway 相似文献(共20条): [1]彭琼辉,刘琼,刘成高,刘梅,李莉莉.热毒宁注射液治疗AECOPD的疗效及对TLR4/NF-κB炎症信号通路的影响[J].湖南中医杂志,2021,37(12):1-...
Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhibit NF-κB signaling. 73 被引用 · 0 笔记 引用 1 2 3 4 5 ••• 15 社区问答 我要提问 Q1 论文试图解决什么问题? Q2 这是否是一个新的...
. Results showed that HCoV-229E activated the NF-кB signaling pathway, and that KD-1 could significantly decrease the HCoV-229E -induced activation of p-NF-κB p65 and p-IκBα, and increase the expression of IκBα (Figs. 5 and 6). We inferred that the mechanism underlying the ...
Redox Regulation of the Nuclear Factor Kappa B (NF-κB) Signaling Pathway and Disease Control 来自 Semantic Scholar 喜欢 0 阅读量: 55 作者:T Okamoto,S Sakurada,JP Yang,N Takahashi 摘要: Nuclear factor kappa B (NF-κB) is an inducible cellular transcription factor that activates various ...
NF-|[kappa]|B signaling, liver disease and hepatoprotective agents The NF-kappaB signaling pathway has particular relevance to several liver diseases including hepatitis (liver infection by Helicobacter, viral hepatitis in... B Sun,M Karin - 《Oncogene》 被引量: 492发表: 2008年 Inhibition of ...
NF-kappa B signaling pathway as a target for human tumor radiosensitization. NF-kappa B is a critical nuclear transcriptional factor that is activated in response to cellular stresses and regulates the expression of genes involved i... M Jung,A Dritschilo - Semin Radiat Oncol 被引量: 174发表...
Throughout simulation study, we can qualitatively validate the developed mathematical model compared with experimental results along this pathway. Further investigations into the TNF mediated NF- B signaling pathway are in progress to include an inhibitor kinase functioning in this pathway. 展开 ...