TLR4NF-kappa BTXNIPAMLOvercoming drug resistance is one of key issues in treating refractory acute myeloid leukemia (AML). The Toll-like receptor 4 (TLR4) signaling pathway is involved in many aspects of biological functions of AML cells, including the regulation of pro-inflammatory cytokine ...
度范围内与TLR4的识别作用有关。随后TLR4主要通过激活下 作用有助于找到控制中枢神经系统损伤的新生物学机制。 游的NF-κB启动凋亡途径, 既往认为NF-κB仅存在细胞核内, 但是最新文献对线粒体依赖的细胞凋亡也同样起着不可忽视的 3 与 介导的线粒体依赖的细胞凋亡途径相关 作用。这些实验的结论无论对线粒体凋亡...
text>Objective: To determine the role of toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappa B) signalling pathway in pulmonary arterial hypertension (PAH) in patients with chronic obstructive pulmonary disease (COPD).Study Design: An experimental study.Place and Duration of Study: Depa...
TLR4-MyD88-TRAF6-TAK1 Complex-Mediated NF-κB Activation Contribute to the Anti-Inflammatory Effect of V8 in LPS-Induced Human Cervical Cancer SiHa Cells TLR4 - MyD88 - TRAF6 - TAK1 Complex - Mediated NF-资B Activation Contribute to the Anti - Inflammatory Effect of V8 in LPS-Induced ...
TLR4/NF-κB signaling pathway is an important regulatory pathway. With the rapid development of the economy, people's dietary structure has changed significantly, and the incidence of hyperlipidemia has been increasing in China [13]. Declaration of competing interest The authors have no conflicts of...
目的:观察热毒宁注射液治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及对Toll样受体4(TLR4)/核转录因子κB(NF-κB)炎症信号通路的影响,并探讨其可能作用机制。方法:将72 例AECOPD患者随机分为治疗组和对照组,每组各36 例。对照组采用西医常规治疗,治疗组在
Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-kappa B signaling pathways through TLR4 Toll-like receptor 4Nuclear factor-kappa BMitogen-activated protein kinasesAnti-inflammationGangliosides, sialic acid-containing glycosphingolWangShenyang...
It has been reported that oxidized low density lipoprotein (oxLDL) inducing formation of foam cells and expression of inflammatory molecules are partly mediated by toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) pathway. However, whether oxLDL/β2-glycoprotein I/anti-β2-...
Interestingly, TLR4/MyD88 pathway but not TLR2 mediates IL-1β secretion in Gd@C82(OH)22 exposure confirmed by macrophages from MyD88//TLR4//TLR2/ knockout mice, which is different from C60(OH)22. Our work demonstrated that fullerenols can greatly activate macrophage and promote IL-1β ...
TLR4NF-kappa BGestational diabetes mellitus (GDM) is a temporary form of diabetes during pregnancy which influences the health of both mother and child. Both inflammation and oxidative stress have been implicated in the pathophysiology of GDM. Apocynin, acetophenone with anti-oxidative and anti-...