我做的就是NF-KB p50在耳蜗的表达，后来也做了p65，我发现在耳蜗p50的表达比p65多，这两种抗体中杉都能买到，我觉的p65/p50二聚体是表达最多的NF-KB抗体，应该都做一下。在一篇文献上看过这样一句“虽然P65和p50是NF-κB的两个重要的亚单位，p50又不同于p65，p50的C末端没有反式激活域，所以...
NF-kappa B p50/p65 affects the frequency of Ly49 gene expression by NK cells. Pascal V,Nathan NR,Claudio E,Siebenlist U,Anderson SK. J Immunol . 2007Pascal V, Nathan NR, Claudio E, Siebenlist U, Anderson SK (2007) NF-kappa B p50/p65 affects the frequency of Ly49 gene expression ...
产品名称: NF-.kappa.B (human p50/p65) Combo Transcription Factor Assay Kit .0 订购此产品 供应商: Cayman 规格: 96 wells 目录价: 5740 库存状态: 3周 CAS编号: 应用范围: 种属来源: 相关信息: NF-κB (human p50/p65) Combo Transcription Factor Assay Kit Cayman Chemical Item Number 10...
In contrast to the p50 dimer, p50-p65 had a strongly reduced requirement for an 11th base pair to efficiently recognize the motif. Only in the presence of spermine could the p50 dimer also efficiently bind to motifs altered in positions 1 or 11, suggesting that DNA bending was important for...
在哺乳动物中该家族有5种蛋白,分别为:RelA(p65),RelB,c-Rel,NF-κB1(p50)和NF-κB2(p52)。它们的N端有着高度保守Rel同源区(Rel homology region,RHR),RHR由N端结构域(N-terminal domain,NTD)和C端结构域(C-terminal domain,CTD)连接而成,在CTD上有一个核定位区域(nuclear-localization sequence, NLS)...
In contrast, p65 delta, a naturally occurring splice variant, fails to markedly augment I kappa B protein levels. Both overexpressed p65 and coexpressed p50 are cytoplasmic, whereas p65 delta is partly nuclear, indicating that the I kappa B induced by p65 can maintain NF-kappa B in the ...
p50/p65是最常见的二聚体形式,其中主要由p65与目的基因结合因此我们选择NF-κB/p65作为我们的研究对象.前期研究已证实,干扰脊髓内NF-κB/p65的表达能够减轻风湿性膝关节炎的疼痛程度,同时还能够改善外周炎症反应.然而,在主要表现为慢性退行性病变而非炎症反应的骨性关节炎中NF-κB/p65是否能够发挥同样的作用却未见...
NF-kappa B, a heterodimeric transcription factor composed of p50 and p65 subunits, can be activated in many cell types and is thought to regulate a wide variety of genes involved in immune function and development. Mice lacking the p50 subunit of NF-kappa B show no developmental abnormalities,...
RelA（p65）、c-Rel和RelB的C端存在反式激活结构域（transactivation domain，TD）使得其激活目标基因。p50和p52只有RHR而缺乏TD，因此，p50和p52同源二聚体并不能激活基因转录，而是作为一种抑制分子存在，它们在细胞内通常各自以其前体p105和p100的形式存在。NF-κB- DNA复合物 NF-κB结合DNA的结构最早是在成熟B...